Evidence map›Paper›PMID 39932807›Full record

ArticleThe Journal of clinical investigation2025

Safety and efficacy of pharmacological inhibition of ketohexokinase in hereditary fructose intolerance.

Evi Jc Koene, Amée M Buziau, David Cassiman, Timothy M Cox, Judith Bons, Jean Ljm Scheijen, Casper G Schalkwijk, Steven Jr Meex, Aditi R Saxena, William P Esler and 3 more

Abstract read
In one paragraph

Article in The Journal of clinical investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Pharmacophore-based virtual screening andFrontiers in pharmacology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Evi Jc KoeneDepartment of Nutrition and Movement Sciences and.
Amée M BuziauDepartment of Internal Medicine, Maastricht University Medical Centre, Maastricht, Netherlands.
David CassimanDepartment Chrometa, KU Leuven, Leuven, Belgium.
Timothy M CoxDepartment of Medicine, University of Cambridge, Cambridge, United Kingdom.
Judith BonsCentral Diagnostic Laboratory, Clinical Chemistry, Maastricht University Medical Centre, Maastricht, Netherlands.
Jean Ljm ScheijenDepartment of Internal Medicine, Maastricht University Medical Centre, Maastricht, Netherlands.
Casper G SchalkwijkDepartment of Internal Medicine, Maastricht University Medical Centre, Maastricht, Netherlands.
Steven Jr MeexCardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, Netherlands.
Aditi R SaxenaInternal Medicine Research Unit, Pfizer Research and Development, Pfizer Inc., Cambridge, Massachusetts, USA.
William P EslerInternal Medicine Research Unit, Pfizer Research and Development, Pfizer Inc., Cambridge, Massachusetts, USA.
Vera B Schrauwen-HinderlingInstitute of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, Maastricht, Netherlands.
Patrick SchrauwenInstitute for Clinical Diabetology, German Diabetes Centre, Leibniz Institute for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Martijn Cgj BrouwersDepartment of Internal Medicine, Maastricht University Medical Centre, Maastricht, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Carbohydrate metabolismClinical trialsDrug therapyEndocrinologyGenetic diseasesMetabolism

Identifiers

PMID39932807
PMCPMC11910217

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.