Evidence map›Paper›PMID 39932763›Full record

ArticleJMIR research protocols2025

Just-In-Time Adaptive Interventions to Promote Behavioral Health: Protocol for a Systematic Review.

Lauren M Henry, Morkeh Blay-Tofey, Clara E Haeffner, Cassandra N Raymond, Elizabeth Tandilashvili, Nancy Terry, Miryam Kiderman, Olivia Metcalf, Melissa A Brotman, Silvia Lopez-Guzman

Abstract read
In one paragraph

Article in JMIR research protocols, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lauren M Henry *Emotion and Development Branch, National Institute of Mental Health, Bethesda, MD, United States.ORCID 0000-0003-0286-9319
Morkeh Blay-Tofey *Emotion and Development Branch, National Institute of Mental Health, Bethesda, MD, United States.ORCID 0009-0000-2320-838X
Clara E HaeffnerEmotion and Development Branch, National Institute of Mental Health, Bethesda, MD, United States.ORCID 0000-0002-7676-8951
Cassandra N RaymondEmotion and Development Branch, National Institute of Mental Health, Bethesda, MD, United States.ORCID 0009-0003-1027-7126
Elizabeth TandilashviliEmotion and Development Branch, National Institute of Mental Health, Bethesda, MD, United States.ORCID 0009-0005-6971-0080
Nancy TerryNational Institutes of Health Library, Office of Research Services, Office of the Director, National Institutes of Health, Bethesda, MD, United States.ORCID 0000-0002-3884-8379
Miryam KidermanEmotion and Development Branch, National Institute of Mental Health, Bethesda, MD, United States.ORCID 0000-0002-2701-8484
Olivia MetcalfPhoenix Australia, Department of Psychiatry, The University of Melbourne, Melbourne, Australia.ORCID 0000-0001-9570-8463
Melissa A BrotmanEmotion and Development Branch, National Institute of Mental Health, Bethesda, MD, United States.ORCID 0000-0002-9859-4702
Silvia Lopez-GuzmanEmotion and Development Branch, National Institute of Mental Health, Bethesda, MD, United States.ORCID 0000-0003-0271-3576

Funding

Unit on Neuroscience and Novel TherapeuticsZIAMH002969 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI BROTMAN, MELISSA · 2019 to 2025
$13.8M
Unit on Computational Decision NeuroscienceZIAMH002981 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI LOPEZ-GUZMAN, SILVIA · 2022 to 2025
$3.2M
Intramural NIH HHS ZIA MH002969Intramural NIH HHS ZIA MH002981
6 · The paper itself

Abstract

backgroundThe goal of just-in-time adaptive interventions (JITAIs) is to use mobile, digital tools to provide individuals with personalized interventions at the optimal time and in the optimal context. Accordingly, JITAIs are promising for advancing accessible, equitable, and evidence-based treatment for behavioral health. To guide future inquiry in this space, a review of the literature is needed to describe the state of research on JITAIs for behavioral health.

objectiveThis study aims to systematically review the literature to describe the landscape of existing JITAIs for behavioral health at any stage of intervention development. In addition, conditional upon a sufficiently homogeneous literature, we will conduct meta-analyses to investigate the effectiveness of JITAIs for promoting distal outcomes (here, aspects of behavioral health) and proximal outcomes (eg, emotion regulation).

methodsThis systematic review is being conducted in accordance with the PRISMA-P (Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols). We developed our search strategy and executed the literature search in collaboration with biomedical librarians; 5 databases (PubMed, Embase, Cochrane Library, Web of Science: Core Collection, and APA PsycINFO) were searched, and results were managed using EndNote 20 (Clarivate). We are screening (title, abstract, and full text) all records in duplicate in Covidence according to eligibility criteria. Data items will be extracted, and risk of bias will be assessed in duplicate from the included articles in Covidence. We will summarize JITAI characteristics in tables and text. We will conduct meta-analyses for the distal and proximal outcomes conditional upon sufficient homogeneity in subgroups. Moderation (conditional upon sufficient heterogeneity of outcomes) and mediation (ie, whether changes in proximal outcomes mediate the relation between JITAIs and distal outcomes) will be conducted as appropriate. We will investigate publication bias and use the Grading of Recommendations Assessment, Development and Evaluation to characterize the quality of evidence of our estimates.

resultsThe search strategy was developed between July 2023 and November 2023. The literature search was executed between November 2023 and December 2023. Title and abstract screening began in December 2023, and full-text screening began in May 2024. Data extraction and analyses have not begun.

conclusionsHere, we propose a systematic review to assess the state of the literature on JITAIs for behavioral health. The insights derived from this study will describe the literature on JITAIs in promoting behavioral health, reinforce JITAI definitions, clarify JITAI elements, and inform the next steps in JITAI research. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): PRR1-10.2196/58917.

Indexed as

Health PromotionMobile ApplicationsHumansMeta-Analysis as TopicResearch DesignSystematic Reviews as TopicTelemedicineaccessibilitybehavioral healthbehavior changedigital treatment deliveryhealth outcomesJITAIjust-in-time adaptive interventionsmobile phonesystematic review

Identifiers

PMID39932763
PMCPMC11862764

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.