Evidence map›Paper›PMID 39932602›Full record

ReviewCurrent cardiology reports2025

From Mechanisms to Management: Tackling In-Stent Restenosis in the Drug-Eluting Stent Era.

Luigi Spadafora, Rossella Quarta, Giovanni Martino, Letizia Romano, Francesco Greco, Antonio Curcio, Tommaso Gori, Carmen Spaccarotella, Ciro Indolfi, Alberto Polimeni

Abstract readReview
In one paragraph

Review in Current cardiology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Luigi SpadaforaDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy. luigispadafora167@gmail.com.
Rossella QuartaDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Rende, Italy.
Giovanni MartinoDivision of Cardiology, Department of Medical and Surgical Sciences, Magna Graecia University, 88100, Catanzaro, Italy.
Letizia RomanoDivision of Cardiology, Department of Medical and Surgical Sciences, Magna Graecia University, 88100, Catanzaro, Italy.
Francesco GrecoDivision of Interventional Cardiology, Annunziata Hospital, 87100, Cosenza, Italy.
Antonio CurcioDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Rende, Italy.
Tommaso GoriDivision of Cardiology, Department of Medical and Surgical Sciences, Magna Graecia University, 88100, Catanzaro, Italy.
Carmen SpaccarotellaDivision of Cardiology, Department of Advanced Biomedical Sciences, University of Naples Federico II, 80126, Naples, Italy.
Ciro IndolfiDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Rende, Italy.
Alberto PolimeniDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036, Rende, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewDrug-eluting stent (DES) technology has greatly enhanced the safety and effectiveness of percutaneous coronary interventions (PCI). The aim of the present paper is to provide a comprehensive review of in-stent restenosis (ISR), focusing on the contemporary DES era, including its incidence, mechanisms, and imaging characterization. RECENT

findingsDespite the widespread use of DES and numerous improvements, recent clinical data indicate that ISR still occurs in 5-10% of PCI procedures, posing a considerable public health issue. The incidence, morphology, and clinical implications of ISR are determined by a complex interplay of several factors: the patient, stent, procedure, and vessel and lesion-related factors. Advancements in intracoronary imaging have provided greater insight into its patterns and underlying causes. Over time, treatment strategies have evolved, and current guidelines recommend an individualized approach using intracoronary imaging to characterize ISR's underlying substrate.

Indexed as

Coronary Artery DiseaseCoronary RestenosisDrug-Eluting StentsPercutaneous Coronary InterventionCoronary AngiographyHumansIncidencecoronary stentDESin-stent restenosisPercutaneous coronary interventions

Identifiers

PMID39932602
PMCPMC11814036

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.