Evidence map›Paper›PMID 39932582›Full record

ArticleJournal of neurology2025

Persistent geotropic or apogeotropic nystagmus: recurrence and association with vestibular migraine.

Tzu-Pu Chang, Ying-Chi Hong, Yu-Hung Kuo, Michael C Schubert

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Article in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Tzu-Pu ChangDepartment of Neurology/Neuro-Medical Scientific Center, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan.
Ying-Chi HongDepartment of Research, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan.
Yu-Hung KuoDepartment of Research, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung, Taiwan.
Michael C SchubertLaboratory of Vestibular NeuroAdaptation, Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins University School of Medicine, 601 North Caroline St, Rm 6245, Baltimore, MD, 21287, USA. mschube1@jhmi.edu.ORCID http://orcid.org/0000-0002-5975-374X

Funding

Buddhist Tzu Chi Medical Foundation TCMF-A 111-07(113)
6 · The paper itself

Abstract

backgroundThe underlying etiologies responsible for persistent geotropic nystagmus (PGN) and apogeotropic nystagmus (PAGN) remain elusive. In this study, we analyzed the symptoms of patients with PGN and PAGN and categorize them based on diagnostic criteria for established vestibular disorders.

methodsClinical signs, recurrences, and duration of vestibular symptoms in patients with PGN or PAGN were collated and included auditory, neurologic, and migrainous symptoms as well as migraine history. Patients were then reclassified into unique etiological groups according to the established diagnostic criteria for vestibular disorders.

resultsAmong 428 patients with nystagmus, 57 (13.3%) presented with PGN or PAGN. Of the 56 patients included in the study, 50 (89.3%) experienced a recurrence of vertigo or dizziness, and 28 (50%) had more than five episodes. Regarding the duration of symptoms, 32 patients (57.1%) experienced vestibular episodes lasting ≤ 1 day, and 46 patients (82.1%) had episodes lasting ≤ 1 week. Based on the available and accepted diagnostic categorization, 17 patients (30.4%) were diagnosed with vestibular migraine, 15 (26.8%) with probable vestibular migraine, 15 (26.8%) with benign recurrent vertigo, 3 (5.4%) with cerebellar lesions, 1 (1.8%) with sudden sensorineural hearing loss, and 5 (8.9%) with undetermined diagnoses.

conclusionsWhile PGN and PAGN can be caused by various vestibular disorders, our data support the majority of cases are episodic and linked to the pathophysiology of vestibular migraine.

Indexed as

Migraine DisordersNystagmus, PathologicVestibular DiseasesAdolescentAdultAgedFemaleHumansMaleMiddle AgedRecurrenceRetrospective StudiesVertigoYoung AdultApogeotropicGeotropicLight cupulaNystagmusVertigoVestibular migraine

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.