Evidence map›Paper›PMID 39932572›Full record

ArticleEuropean journal of nutrition2025

Association between erythrocyte polyunsaturated fatty acids and gestational diabetes mellitus in Chinese pregnant women.

Nu Tang, Yannan He, Shamshad Karatela, Jinjing Zhong, Xiaoling Zeng, Qinggui Lu, Feng Zhao, Li Cai

Registry-linked trialAbstract read
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In one paragraph

Article in European journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03023293 (Effects and Mechanisms of n-3 Polyunsaturated Fatty Acids and Irisin on Maternal Abnormal Glucose Metabolism From Pregnancy to Postpartum), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03023293 completednot on this map

Effects and Mechanisms of n-3 Polyunsaturated Fatty Acids and Irisin on Maternal Abnormal Glucose Metabolism From Pregnancy to Postpartum

TypeobservationalSponsorSun Yat-sen UniversityRan2017 to 2025Enrolled1,122ConditionsGestational Diabetes Mellitus, Neurodevelopmental Disorders, Postpartum Abnormal Glucose Metabolism, Child Growth and DevelopmentArmsNo intervention
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nu TangDepartment of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, China.ORCID http://orcid.org/0000-0001-8258-5767
Yannan HeInstitute of Nutrition & Health, Qingdao University, Qingdao, 266071, China.
Shamshad KaratelaFaculty of Health and Behavioural Sciences, Pharmacy Australia Centre of Excellence, University of Queensland, Woolloongabba, QLD, Australia.
Jinjing ZhongHyproca Nutrition Co., Ltd, Changsha, 410000, China.
Xiaoling ZengAusnutria Dairy (China) Co., Ltd, Changsha, Hunan Province, 410219, China.
Qinggui LuDepartment of Health Care, Maternal and Child Health Care Hospital of Yuexiu District, Guangzhou, 510080, China.
Feng ZhaoCenter of Lipid & Chronic diseases, Suzhou Industrial Technology Research Institute, Zhejiang University, Suzhou, 215163, China. fengzhao21c@163.com.
Li CaiDepartment of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, China. caili5@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0002-8579-5986

Funding

Ausnutria-Kabrita Research Grant RS2023-08Basic and Applied Basic Research Foundation of Guangdong Province 2023A1515030192Guangzhou Health Science and Technology General Guidance Project 20241A010088the Chongqing Research Center for Prevention & Control of Maternal and Child Diseases and Public Health the Chongqing Research Center for Prevention & Control of Maternal and Child Diseases and Public Health
6 · The paper itself

Abstract

purposeTo explore the associations of erythrocyte polyunsaturated fatty acids (PUFAs) with the risk of gestational diabetes mellitus (GDM) in pregnant women.

methodsA total of 951 women in mid-pregnancy (20-28 weeks of gestation) were recruited during 2017-2018. Erythrocyte PUFAs were measured by gas chromatography and expressed as a percentage of total fatty acids. A 75 g oral glucose tolerance test was used for GDM diagnosis. Logistic regression and restricted cubic spline models were conducted.

resultsAmong the 951 pregnant women, 180 were diagnosed with GDM (18.93%). For n-3 PUFAs, each standard deviation (SD) increase in α-linolenic acid (ALA) and docosapentaenoic acid (DPA) was associated with multivariable-adjusted odds ratios (ORs) of 0.789 (95% CI: 0.649, 0.961; P = 0.018) and 0.782 (95% CI: 0.638, 0.957; P = 0.017), respectively. However, the associations became marginally significant after post hoc false-discovery rate (FDR) correction (both P

conclusionErythrocyte GLA was significantly associated with an increased risk of GDM in pregnant women. Furthermore, we observed for the first time significant non-linear associations of erythrocyte ALA and GLA with GDM risk. CLINICAL TRIAL REGISTRY NUMBER: NCT03023293, 2019-01-11.

Indexed as

Diabetes, GestationalErythrocytesFatty Acids, UnsaturatedAdultalpha-Linolenic AcidChinaEast Asian PeopleFemaleGlucose Tolerance TestHumansPregnancyRisk Factorsalpha-Linolenic AcidFatty Acids, UnsaturatedErythrocyteGestational diabetes mellitusPolyunsaturated fatty acidsPregnant women

Identifiers

PMID39932572

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.