Evidence map›Paper›PMID 39932536›Full record

ArticleEuropean journal of applied physiology2025

Cluster sets and traditional sets elicit similar muscular hypertrophy: a volume and effort-matched study in resistance-trained individuals.

Salvador Vargas-Molina, Manuel García-Sillero, Sergio Maroto-Izquierdo, Eneko Baz-Valle, Borja Bautista-Mayorga, Mora Murri, Brad J Schoenfeld, Javier Benítez-Porres

Abstract read
In one paragraph

Article in European journal of applied physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Trial
  4. Trial
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Salvador Vargas-MolinaPhysical Education and Sport, Faculty of Medicine, University of Málaga, Málaga, Spain.ORCID https://orcid.org/0000-0001-6775-9159
Manuel García-SilleroPhysical Education and Sport, Faculty of Medicine, University of Málaga, Málaga, Spain.ORCID https://orcid.org/0000-0002-3022-9151
Sergio Maroto-Izquierdoi+HeALTH, European University Miguel de Cervantes, Valladolid, Spain.ORCID https://orcid.org/0000-0002-6696-5636
Eneko Baz-ValleDepartment of Physical Education and Sport, University of the Basque Country UPV/EHU Vitoria-Gasteiz, Vitoria-Gasteiz, Spain.ORCID https://orcid.org/0000-0002-2157-7488
Borja Bautista-MayorgaEADE-University of Wales Trinity Saint David, Málaga, Spain.
Mora MurriEndocrinology and Nutrition Clinical Management Unit, Hospital Clínico Virgen de la Victoria; Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Málaga, Spain. moramurri@gmail.com.
Brad J SchoenfeldDepartment of Exercise Science and Recreation, CUNY Lehman College, Bronx, NY, USA.ORCID https://orcid.org/0000-0003-4979-5783
Javier Benítez-PorresPhysical Education and Sport, Faculty of Medicine, University of Málaga, Málaga, Spain. benitez@uma.es.ORCID https://orcid.org/0000-0001-7546-7965

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivePrevious studies examining the effects of cluster sets (CS) compared to traditional sets (TS) protocols on muscle hypertrophy have primarily equated to volume load. This inevitably has resulted in a lower number of repetitions performed in TS compared to CS, thereby leading to a suboptimal hypertrophic stimulus. The present study aimed to compare the impact of CS and TS protocols, both performed with the same number of sets and repetitions, but with loads adjusted to the same range of repetitions in reserve (RIR) on muscle hypertrophy.

methodsTen resistance-trained volunteers (7 men and 3 women, 21.0 ± 1.5 years, 64.3 ± 6.9 kg, and 169.3 ± 6.2 cm) participated in this study. Participants performed two training protocols over an 8-week period, with two weekly sessions consisting of 5 sets of 12 repetitions of the leg press and leg extension exercises. The study employed a within-participant, unilateral design where one limb performed a TS protocol and the contralateral limb performed 3 clusters of 4 repetitions with a 20-s intra-set rest period of the same exercises (CS). Muscle thickness was assessed via ultrasound and thigh lean tissue mass was assessed by dual-energy X-ray absorptiometry pre- and post-study.

resultsResults showed similar increases in muscle thickness (p < 0.001, ES = 0.56, and p = 0.012, ES = 0.42, respectively) and lean tissue mass (p = 0.002, ES = 0.11, and p < 0.001, ES = 0.13, respectively) in both CS and TS conditions.

conclusionIn conclusion, when sets, repetitions, and load adjustments were equalized based on RIR, a CS protocol elicits similar increases in muscle thickness and lean mass compared to a TS protocol.

Indexed as

Muscle, SkeletalResistance TrainingAdultFemaleHumansHypertrophyMaleMuscle StrengthYoung AdultBody buildingBody compositionDrop setsHypertrophyMuscle-massRest-pause training

Identifiers

PMID39932536
PMCPMC12174233

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.