ArticleEuropean journal of applied physiology2025
Cluster sets and traditional sets elicit similar muscular hypertrophy: a volume and effort-matched study in resistance-trained individuals.
Article in European journal of applied physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Effects of Advanced Resistance Training Prescription Methods on Strength, Power, Hypertrophy, and Performance Adaptations in Healthy Adults: A Systematic Review and Bayesian Network Meta-analysis.Sports medicine (Auckland, N.Z.) · 2026Pooled it
- Effects of Continuous and Cluster-Set Configurations Performed to Failure on Performance and Physiological Responses in the Bench Press and Half Squat.Scandinavian journal of medicine & science in sports · 2026Trial
- Acute Responses and Chronic Adaptations to Cluster Versus Traditional Set Resistance Training in Males and Females.European journal of sport science · 2026Trial
- Effects of deload periods in resistance training on muscle hypertrophy and strength endurance in untrained young men using a randomized within subject design.Scientific reports · 2026Trial
- Effects of Advanced Resistance Training Systems on Muscle Hypertrophy and Strength in Recreationally Trained Adults: A Systematic Review and Meta-Analysis.Journal of functional morphology and kinesiology · 2026Review
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Authors and funding
8 authors.
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Abstract
BACKGROUND AND
objectivePrevious studies examining the effects of cluster sets (CS) compared to traditional sets (TS) protocols on muscle hypertrophy have primarily equated to volume load. This inevitably has resulted in a lower number of repetitions performed in TS compared to CS, thereby leading to a suboptimal hypertrophic stimulus. The present study aimed to compare the impact of CS and TS protocols, both performed with the same number of sets and repetitions, but with loads adjusted to the same range of repetitions in reserve (RIR) on muscle hypertrophy.
methodsTen resistance-trained volunteers (7 men and 3 women, 21.0 ± 1.5 years, 64.3 ± 6.9 kg, and 169.3 ± 6.2 cm) participated in this study. Participants performed two training protocols over an 8-week period, with two weekly sessions consisting of 5 sets of 12 repetitions of the leg press and leg extension exercises. The study employed a within-participant, unilateral design where one limb performed a TS protocol and the contralateral limb performed 3 clusters of 4 repetitions with a 20-s intra-set rest period of the same exercises (CS). Muscle thickness was assessed via ultrasound and thigh lean tissue mass was assessed by dual-energy X-ray absorptiometry pre- and post-study.
resultsResults showed similar increases in muscle thickness (p < 0.001, ES = 0.56, and p = 0.012, ES = 0.42, respectively) and lean tissue mass (p = 0.002, ES = 0.11, and p < 0.001, ES = 0.13, respectively) in both CS and TS conditions.
conclusionIn conclusion, when sets, repetitions, and load adjustments were equalized based on RIR, a CS protocol elicits similar increases in muscle thickness and lean mass compared to a TS protocol.
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