Evidence map›Paper›PMID 39932513›Full record

ArticleJournal of neurology2025

Glymphatic system dysfunction as a biomarker of disease progression in Parkinson's disease: neuroimaging evidence from longitudinal cohort studies.

Junli Ren, Dongling Xie, Lingsheng Wang, Zihao Wu, Shenyi Lin, Qiaoqiao Jin, Yuwen Luo, Baoyi Zhu, Haoyang Huang, Junchao Wang and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Junli Ren *Department of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Dongling Xie *Department of Radiology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Lingsheng Wang *The First School of Medicine, School of Information and Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Zihao WuThe First School of Medicine, School of Information and Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Shenyi LinThe First School of Medicine, School of Information and Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Qiaoqiao JinThe First School of Medicine, School of Information and Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Yuwen LuoThe First School of Medicine, School of Information and Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Baoyi ZhuThe School of Mental Health, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Haoyang HuangThe Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Junchao WangThe Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Shishu ZhangRenji College, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Zijia LiuThe Second School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Guangyong ChenDepartment of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Min LuoDepartment of Radiology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China. lm95113@wmu.edu.
Dehao YangDepartment of Neurology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, Zhejiang, China. dehao_yang@zju.edu.cn.ORCID http://orcid.org/0000-0002-4129-9761

Funding

the Fundamental Research Funds for the Central Universities No. 2023FZZX05-02the National Natural Science Foundation of China No. 82302081the Zhejiang Provincial Natural Science Foundation of China No. LQ24H090003
6 · The paper itself

Abstract

BACKGROUND AND

objectiveThe brain glymphatic system is involved in the clearance of misfolded α-synuclein, and the impaired glymphatic system may contribute to the progression of Parkinson's disease (PD). This study aimed to investigate the association between glymphatic function, as assessed by the diffusion tensor image analysis along the perivascular space (DTI-ALPS) index, and disease progression in PD.

methodsOne hundred thirty nine PD patients and 62 healthy controls (HCs) were enrolled in this prospective cohort study and followed up for 4 years. At baseline and 1-, 2-, and 4-year follow-ups, the enrolled population was examined with DTI scans, and the ALPS index was calculated. Unified Parkinson's Disease Rating Scale (UPDRS)-III and Montreal Cognitive Assessment (MoCA) were used to assess the motor and cognitive functions of the patients, respectively.

resultThe ALPS index was significantly lower in PD patients compared with HCs. Receiver operating characteristic curve analysis demonstrated that the ALPS index had a great diagnostic ability on PD, both at baseline and subsequent follow-ups (AUC

conclusionThe ALPS index could be used as an early potential imaging marker not only to differentiate PD patients from HCs but also to predict longitudinal motor function progression in PD.

Indexed as

Disease ProgressionGlymphatic SystemParkinson DiseaseAgedBiomarkersCohort StudiesDiffusion Tensor ImagingFemaleFollow-Up StudiesHumansLongitudinal StudiesMaleMiddle AgedNeuroimagingProspective StudiesBiomarkersDiffusion tensor imagingGlymphatic systemLongitudinal studyParkinson’s disease

Identifiers

PMID39932513

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.