Evidence map›Paper›PMID 39932512›Full record

ReviewCurrent pain and headache reports2025

Biologic Therapies for Discogenic Pain.

Jesse Lou, Rabiul Ryan, Dajie Wang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current pain and headache reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jesse LouDepartment of Anesthesiology, Jefferson Pain Center, Sidney Kimmel Medical College at Thomas ,Jefferson University, Philadelphia, PA, U.S.A.
Rabiul RyanDepartment of Anesthesiology, Jefferson Pain Center, Sidney Kimmel Medical College at Thomas ,Jefferson University, Philadelphia, PA, U.S.A.
Dajie WangDepartment of Anesthesiology, Jefferson Pain Center, Sidney Kimmel Medical College at Thomas ,Jefferson University, Philadelphia, PA, U.S.A.. Dajie.Wang@jefferson.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThe purpose of this review is to provide an update on recent developments in the field of regenerative medicine, specifically focusing on emerging data related to biologics, including platelet-rich plasma and mesenchymal cells, for the treatment of discogenic back pain. RECENT

findingsThere has been a notable surge of interest in biologics, as evidenced by a wealth of recent reviews and studies. While serious adverse events are generally uncommon, considerable heterogeneity exists in study designs. More robust investigations are warranted to thoroughly evaluate the safety and efficacy of biologics in treating discogenic back pain. Continued research and funding are needed to better understand the underlying mechanisms of disc degeneration and to develop targeted therapies that can alleviate and reduce the burden of this debilitating condition. Biologics may offer effective treatments for discogenic pain; however, more multi-center, prospective, double-blinded, randomized placebo-controlled trials are essential to further establish their effectiveness.

Indexed as

Back PainBiological ProductsBiological TherapyIntervertebral Disc DegenerationHumansPlatelet-Rich PlasmaBiological ProductsBiologicsDegenerative disc diseaseDiscogenic back painMesenchymal stem cellsPlatelet-rich plasma

Identifiers

PMID39932512

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.