Evidence map›Paper›PMID 39932415›Full record

ArticleRadiology2025

Hormonal Regulation of Background Parenchymal Enhancement at Contrast-enhanced Mammography.

Noam Nissan, Varadan Sevilimedu, Jill Gluskin, Yuki Arita, Delia M Keating, Donna D'Alessio, Hila Fruchtman-Brot, R Elena Ochoa-Albiztegui, Janice S Sung, Maxine S Jochelson

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PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Noam NissanFrom the Departments of Radiology (N.N., J.G., Y.A., D.M.K., D.D., H.F.B., R.E.O.A., J.S.S., M.S.J.) and Epidemiology and Biostatistics (V.S.), Memorial Sloan Kettering Cancer Center, 300 E 66th St, New York, NY 100065.ORCID 0000-0001-5416-4199
Varadan SevilimeduFrom the Departments of Radiology (N.N., J.G., Y.A., D.M.K., D.D., H.F.B., R.E.O.A., J.S.S., M.S.J.) and Epidemiology and Biostatistics (V.S.), Memorial Sloan Kettering Cancer Center, 300 E 66th St, New York, NY 100065.ORCID 0000-0002-0938-9396
Jill GluskinFrom the Departments of Radiology (N.N., J.G., Y.A., D.M.K., D.D., H.F.B., R.E.O.A., J.S.S., M.S.J.) and Epidemiology and Biostatistics (V.S.), Memorial Sloan Kettering Cancer Center, 300 E 66th St, New York, NY 100065.ORCID 0000-0002-6966-7597
Yuki AritaFrom the Departments of Radiology (N.N., J.G., Y.A., D.M.K., D.D., H.F.B., R.E.O.A., J.S.S., M.S.J.) and Epidemiology and Biostatistics (V.S.), Memorial Sloan Kettering Cancer Center, 300 E 66th St, New York, NY 100065.ORCID 0000-0002-5285-0352
Delia M KeatingFrom the Departments of Radiology (N.N., J.G., Y.A., D.M.K., D.D., H.F.B., R.E.O.A., J.S.S., M.S.J.) and Epidemiology and Biostatistics (V.S.), Memorial Sloan Kettering Cancer Center, 300 E 66th St, New York, NY 100065.ORCID 0000-0002-4849-2273
Donna D'AlessioFrom the Departments of Radiology (N.N., J.G., Y.A., D.M.K., D.D., H.F.B., R.E.O.A., J.S.S., M.S.J.) and Epidemiology and Biostatistics (V.S.), Memorial Sloan Kettering Cancer Center, 300 E 66th St, New York, NY 100065.ORCID 0000-0002-2500-6770
Hila Fruchtman-BrotFrom the Departments of Radiology (N.N., J.G., Y.A., D.M.K., D.D., H.F.B., R.E.O.A., J.S.S., M.S.J.) and Epidemiology and Biostatistics (V.S.), Memorial Sloan Kettering Cancer Center, 300 E 66th St, New York, NY 100065.ORCID 0000-0003-0533-5910
R Elena Ochoa-AlbizteguiFrom the Departments of Radiology (N.N., J.G., Y.A., D.M.K., D.D., H.F.B., R.E.O.A., J.S.S., M.S.J.) and Epidemiology and Biostatistics (V.S.), Memorial Sloan Kettering Cancer Center, 300 E 66th St, New York, NY 100065.ORCID 0000-0002-5443-6702
Janice S SungFrom the Departments of Radiology (N.N., J.G., Y.A., D.M.K., D.D., H.F.B., R.E.O.A., J.S.S., M.S.J.) and Epidemiology and Biostatistics (V.S.), Memorial Sloan Kettering Cancer Center, 300 E 66th St, New York, NY 100065.ORCID 0000-0002-9067-9840
Maxine S JochelsonFrom the Departments of Radiology (N.N., J.G., Y.A., D.M.K., D.D., H.F.B., R.E.O.A., J.S.S., M.S.J.) and Epidemiology and Biostatistics (V.S.), Memorial Sloan Kettering Cancer Center, 300 E 66th St, New York, NY 100065.ORCID 0000-0002-4012-2470

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Background Background parenchymal enhancement (BPE) is an important diagnostic and prognostic imaging biomarker. Although hormonal regulation of BPE at breast MRI has been investigated, information regarding hormonal regulation of BPE at contrast-enhanced mammography (CEM) remains scarce. Purpose To investigate how BPE at CEM changes across various short- and long-term physiologic and pharmacologic hormonal effects, including menopausal status, lactation, hormone replacement therapy (HRT), and tamoxifen therapy and its cessation. Materials and Methods This retrospective study included CEM examinations performed between December 2012 and January 2024. A computational search was performed to identify CEMs performed in patients with various hormonal statuses and several subgroups of patients were identified, including premenopausal, postmenopausal, lactating, HRT, and tamoxifen subgroups. For patients who received tamoxifen therapy, the first follow-up image at treatment cessation was included, when available. The four ordinal BPE grades, ranging from minimal to marked, as reported in the official radiologic reports were used for analysis. Subgroup comparisons were performed using the Kruskal-Wallis rank sum test and χ

Indexed as

Breast NeoplasmsContrast MediaMammographyAdultAgedBreastFemaleHormone Replacement TherapyHumansLactationMiddle AgedRetrospective StudiesTamoxifenContrast MediaTamoxifen

Identifiers

PMID39932415
PMCPMC11868820

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.