Evidence map›Paper›PMID 39932309›Full record

ArticleMicrobiology spectrum2025

The impact of aztreonam-clavulanic acid exposure on gene expression and mutant selection using a multidrug-resistant

Tongtong Lin, Jiayuan Zhang, Shuo Diao, Jinke Yan, Kexin Zhang, Jichao Cao, Junyi Huang, Yaohai Wang, Zhihua Lv, Xiaopeng Shen and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Optimization of pediatric dosing regimens for aztreonam and amoxicillin/clavulanate combination therapy against multidrug-resistant bacteria.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  2. Detection of theVeterinary world · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tongtong Lin *Key Laboratory of Evolution & Marine Biodiversity (Ministry of Education) and Institute of Evolution & Marine Biodiversity, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong Province, China.ORCID 0000-0002-3515-2018
Jiayuan Zhang *Key Laboratory of Evolution & Marine Biodiversity (Ministry of Education) and Institute of Evolution & Marine Biodiversity, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong Province, China.
Shuo DiaoKey Laboratory of Evolution & Marine Biodiversity (Ministry of Education) and Institute of Evolution & Marine Biodiversity, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong Province, China.
Jinke YanKey Laboratory of Evolution & Marine Biodiversity (Ministry of Education) and Institute of Evolution & Marine Biodiversity, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong Province, China.
Kexin ZhangKey Laboratory of Evolution & Marine Biodiversity (Ministry of Education) and Institute of Evolution & Marine Biodiversity, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong Province, China.
Jichao CaoKey Laboratory of Evolution & Marine Biodiversity (Ministry of Education) and Institute of Evolution & Marine Biodiversity, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong Province, China.
Junyi HuangKey Laboratory of Evolution & Marine Biodiversity (Ministry of Education) and Institute of Evolution & Marine Biodiversity, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong Province, China.
Yaohai WangKey Laboratory of Evolution & Marine Biodiversity (Ministry of Education) and Institute of Evolution & Marine Biodiversity, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong Province, China.
Zhihua LvKey Laboratory of Evolution & Marine Biodiversity (Ministry of Education) and Institute of Evolution & Marine Biodiversity, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong Province, China.
Xiaopeng ShenCollege of Life Sciences, Anhui Normal University, Wuhu, Anhui Province, China.
Sherwin K B SyDepartment of Statistics, State University of Maringá, Maringá, Paraná, Brazil.ORCID 0000-0001-6405-9130
Michael LynchBiodesign Center for Mechanisms of Evolution, Arizona State University, Tempe, USA.
Hongan LongKey Laboratory of Evolution & Marine Biodiversity (Ministry of Education) and Institute of Evolution & Marine Biodiversity, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong Province, China.ORCID 0000-0001-9767-8173
Mingming YuKey Laboratory of Evolution & Marine Biodiversity (Ministry of Education) and Institute of Evolution & Marine Biodiversity, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong Province, China.ORCID 0000-0001-9504-891X

Funding

Causes and Population-genetic Consequences of Molecular VariationR35GM122566 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI Michael R LYNCH · 2017 to 2026
$7.7M
NIGMS NIH HHS R35 GM122566
6 · The paper itself

Abstract

Multidrug-resistant

Indexed as

Anti-Bacterial AgentsAztreonambeta-Lactamase InhibitorsClavulanic AcidDrug Resistance, Multiple, BacterialEscherichia coliGene Expression Regulation, Bacterialbeta-LactamasesEscherichia coli InfectionsEscherichia coli ProteinsGene Expression ProfilingHumansMicrobial Sensitivity TestsMutationAnti-Bacterial AgentsAztreonambeta-Lactamase Inhibitorsbeta-LactamasesClavulanic AcidEscherichia coli Proteinsantibiotic combinationevolutionmutagenesisresistance mutations

Identifiers

PMID39932309
PMCPMC11878011

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.