Evidence map›Paper›PMID 39932273›Full record

ArticlemBio2025

Borrelial phosphomannose isomerase as a cell surface localized protein that retains enzymatic activity and promotes host-pathogen interaction.

Shraboni Dutta, Vipin S Rana, Brian T Backstedt, Anil K Shakya, Chrysoula Kitsou, Ozlem B Yas, Alexis A Smith, Michael H Ronzetti, Rachel M Lipman, Sarai Araujo-Aris and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Shraboni Dutta *Department of Veterinary Medicine, University of Maryland, College Park, Maryland, USA.
Vipin S Rana *Department of Veterinary Medicine, University of Maryland, College Park, Maryland, USA.
Brian T Backstedt *Department of Veterinary Medicine, University of Maryland, College Park, Maryland, USA.
Anil K ShakyaInstitute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland, USA.
Chrysoula KitsouDepartment of Veterinary Medicine, University of Maryland, College Park, Maryland, USA.
Ozlem B YasDepartment of Microbiology, Faculty of Veterinary Medicine, Ondokuz Mayis University, Samsun, Turkey.
Alexis A SmithDepartment of Veterinary Medicine, University of Maryland, College Park, Maryland, USA.
Michael H RonzettiNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, USA.
Rachel M LipmanDepartment of Veterinary Medicine, University of Maryland, College Park, Maryland, USA.
Sarai Araujo-ArisCIC bioGUNE-BRTA (Basque Research and Technology Alliance), Derio, Bizkaia, Spain.
Xiuli YangDepartment of Veterinary Medicine, University of Maryland, College Park, Maryland, USA.
Ganesha RaiNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, USA.
Yi-Pin LinDepartment of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, Maryland, USA.ORCID 0000-0002-5240-2031
Osnat HerzbergInstitute for Bioscience and Biotechnology Research, University of Maryland, Rockville, Maryland, USA.ORCID 0000-0003-2823-7627
Utpal PalDepartment of Veterinary Medicine, University of Maryland, College Park, Maryland, USA.ORCID 0000-0002-7504-4628

Funding

BORRELIA GENE PRODUCTS CRITICAL FOR NATURAL INFECTION CYCLER01AI080615 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI PAL, UTPAL · 2009 to 2024
$5.2M
Immunomodulatory mechanisms of wild bird reservoir hosts that facilitate persistence of Lyme disease bacteriaR01AI181746 · NIAID · TUFTS UNIVERSITY BOSTON · PI Yi-Pin Lin · 2024 to 2026
$2.5M
Training in Host-pathogens interactionsT32AI089621 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI LEE, VINCENT T, MCIVER, KEVIN S. · 2010 to 2025
$2.1M
BBA57-Mediated Borrelial Persistence, Genesis of Inflammation and ImmunityR01AI116620 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI PAL, UTPAL · 2015 to 2019
$1.9M
Identification of the mechanism of protection against a B. burgdorferi protein CspZ for the prevention of Lyme diseaseR21AI144891 · NIAID · WADSWORTH CENTER · PI BOTTAZZI, MARIA ELENA, LIN, YI-PIN · 2020 to 2021
$441k
Borella Gene Products Critical For Natural Infection CycleR56AI080615 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI PAL, UTPAL · 2013 to 2013
$357k
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI080615, AI116620HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI144891, AI181746NIAID NIH HHS R01 AI080615NIAID NIH HHS R01 AI116620NIAID NIH HHS R01 AI181746NIAID NIH HHS R21 AI144891NIAID NIH HHS R56 AI080615NIAID NIH HHS T32 AI089621
6 · The paper itself

Abstract

All organisms produce an intracellular Zn IMPORTANCE: All organisms produce an intracellular enzyme, phosphomannose isomerase (PMI), that converts specific sugars during metabolism. Unexpectedly, we discovered an additional PMI function in

Indexed as

Bacterial ProteinsBorrelia burgdorferiHost-Pathogen InteractionsMannose-6-Phosphate IsomeraseAnimalsFemaleHumansLyme DiseaseMiceBacterial ProteinsMannose-6-Phosphate Isomerasehost-pathogen interactionlyme disease pathogenmoonlightingphosphomannose isomerase

Identifiers

PMID39932273
PMCPMC11898738

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.