Evidence map›Paper›PMID 39931999›Full record

ReviewStem cells translational medicine2025

Assessment of immune modulation strategies to enhance survival and integration of human neural progenitor cells in rodent models of spinal cord injury.

Zijian Lou, Alex Post, Narihito Nagoshi, James Hong, Nader Hejrati, Jonathon Chon Teng Chio, Mohamad Khazaei, Michael G Fehlings

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cells translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zijian LouDivision of Genetics and Development, Krembil Brain Institute, University Health Network, Toronto, ON, CanadaM5T 0S8.
Alex PostDivision of Genetics and Development, Krembil Brain Institute, University Health Network, Toronto, ON, CanadaM5T 0S8.
Narihito NagoshiDivision of Genetics and Development, Krembil Brain Institute, University Health Network, Toronto, ON, CanadaM5T 0S8.
James HongDivision of Genetics and Development, Krembil Brain Institute, University Health Network, Toronto, ON, CanadaM5T 0S8.
Nader HejratiDivision of Genetics and Development, Krembil Brain Institute, University Health Network, Toronto, ON, CanadaM5T 0S8.
Jonathon Chon Teng ChioDivision of Genetics and Development, Krembil Brain Institute, University Health Network, Toronto, ON, CanadaM5T 0S8.
Mohamad KhazaeiDivision of Genetics and Development, Krembil Brain Institute, University Health Network, Toronto, ON, CanadaM5T 0S8.
Michael G FehlingsDivision of Genetics and Development, Krembil Brain Institute, University Health Network, Toronto, ON, CanadaM5T 0S8.ORCID 0000-0002-5722-6364

Funding

CIHRKrembil FoundationWings for Life
6 · The paper itself

Abstract

Regenerative therapies are currently lacking for spinal cord injury (SCI). Neural progenitor cells (NPCs) have emerged as a promising therapeutic approach. To facilitate translation of NPCs into the clinic, studying human NPCs in rodent models is required. The preclinical study of human NPCs in rodent models of SCI necessitates an optimal selection of immunomodulatory strategies, requiring a balance between modulating the immune system and preserving its functionality.

Indexed as

ImmunomodulationNeural Stem CellsSpinal Cord InjuriesStem Cell TransplantationAnimalsCell SurvivalDisease Models, AnimalHumansRatsgene expressionimmunosuppressionneural progenitor cellsspinal cord injurytransplantation

Identifiers

PMID39931999
PMCPMC11811735

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.