ArticleCurrent medicinal chemistry2026
A Correlation between Sequential Organ Failure Assessment Scores and Biomarkers of Inflammation and Infection in Patients with Sepsis.
Article in Current medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Distinct patterns of endothelial response to endotoxin in aged mice as compared to young mice.GeroScience · 2026Article
- Organ Injury, Protection and Interactions: Novel Targets, Drugs, and Mechanisms.Current medicinal chemistry · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSepsis has a high mortality rate. While early diagnosis is crucial, there are no effective inflammatory or infectious markers for the diagnosis and prediction of sepsis.
objectiveThe present study aimed to establish a correlation between inflammatory and infectious markers and the severity of sepsis at a genetic and cross-sectional level.
methodsUsing transcriptomic and clinical data from the GEO and Dryad databases, we analyzed the expression of eight indicators of inflammatory infection, as well as their diagnostic efficacy. Additionally, we investigated the correlation between eight plasma biomarkers and the Sequential Organ Failure Assessment (SOFA) score in sepsis.
resultsAngiotensin II (Ang-2), fractalkine, interleukin-1 receptor antagonist (IL-1ra), pentraxin 3 (PTX-3), and tumor necrosis factor (TNF)-α type 1 receptor (TNFR1) were up-regulated in sepsis and septic shock. Ang-2, IL-1ra, and PTX-3 had high diagnostic efficacy in both sepsis and septic shock. They also recruited chemokines to generate inflammatory storms, thereby exacerbating the progression of sepsis. Finally, we examined 153 adult non-trauma patients enrolled in the University of Pittsburgh Acute Lung Injury Registry (SOFA score > 2). Ang-2, suppressor of tumorigenicity 2 (ST-2), fractalkine, IL-1ra, TNFR1, procalcitonin (PCT), and PTX-3, but not C-peptide were significantly more expressed in the plasma of the severe sepsis group than in the mild sepsis group. Significant nonlinear correlations were detected between Ang-2, ST-2, IL-1ra, TNFR1, PCT, and PTX-3 levels and SOFA scores.
conclusionOur analysis revealed that Ang-2, IL-1ra, and PTX-3 correlated strongly with septic shock at the gene and protein levels, exhibiting nonlinear associations up to a certain point. These findings will facilitate the diagnosis and prognosis of septic shock.
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Registered trials
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