Evidence map›Paper›PMID 39931854›Full record

ArticleCurrent Alzheimer research2024

Discovery of Selective β-Secretase (BACE-1) Inhibitors by the Solid-Phase Synthesis of Small Molecular-sized Peptides.

Khair Ullah, Mikhlid H Almutairi, Muhammad Naseer Abbas, Abdul Wahab, Sundas Nayab, Fozia Fozia, Muhammad Asghar Khan, Zafar Ali Shah, Ijaz Ahmad, Bader O Almutairi and 1 more

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Article in Current Alzheimer research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Khair UllahDepartment of Biochemistry, Abdul Wali Khan University, Mardan, Khyber Pakhtunkhwa, Pakistan.
Mikhlid H AlmutairiZoology Department, College of Science, King Saud University, P.O. Box: 2455, 11451, Riyadh, Saudi Arabia.
Muhammad Naseer AbbasDepartment of Pharmacy, KUST, Kohat, Khyber Pakhtunkhwa, Pakistan.
Abdul WahabDepartment of Pharmacy, KUST, Kohat, Khyber Pakhtunkhwa, Pakistan.
Sundas NayabDepartment of Chemistry, University of Swabi, Khyber Pakhtunkhwa, Pakistan.
Fozia FoziaDepartment of Biochemistry, Khyber Medical University Institute of Dental Sciences, Kohat, Pakistan.
Muhammad Asghar KhanDepartment of Pharmacy, University of Malakand, Khyber Pakhtunkhwa, Pakistan.
Zafar Ali ShahKey Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
Ijaz AhmadDepartment of Chemistry, Kohat University of Science & Technology, Kohat, Khyber Pakhtunkhwa, Pakistan.
Bader O AlmutairiZoology Department, College of Science, King Saud University, P.O. Box: 2455, 11451, Riyadh, Saudi Arabia.
Ziaullah ZiaullahCollege of Professional Studies, Northeastern University, Boston, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAlzheimer's disease (AD) is a progressive neurological disorder for which no effective cure currently exists. Research has identified β-Secretase (BACE1) as a promising therapeutic target for the management of AD. BACE1 is involved in the rate-limiting step and produces toxic amyloid-beta (Aβ) peptides that lead to deposits in the form of amyloid plaques extracellularly, resulting in AD.

methodIn this connection, 60 small peptides were evaluated for their

resultsThe identified hit peptides were synthesized using Solid-Phase Peptide Synthesis (SPPS), and Electrospray Ionization Mass Spectrometry (ESI-MS) elucidated their structures and 1 1 HNMR spectroscopy. According to their

conclusionAccording to the cytotoxicity study, peptide 21 was found to be noncytotoxic at 4.64 μM, 10 μM and 20 μM. The forthcoming target of this study is to evaluate further the effect of peptide 21 in an in-vivo mice model.

Indexed as

Amyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesEnzyme InhibitorsPeptidesAlzheimer DiseaseAnimalsDrug DiscoveryHumansMiceSolid-Phase Synthesis TechniquesAmyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesBACE1 protein, humanEnzyme InhibitorsPeptides1H-NMRAlzheimer's diseaseESI-MSin silicoin-vitropeptides synthesissolid-phase synthesis.β-secretase (BACE1)

Identifiers

PMID39931854

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.