Evidence map›Paper›PMID 39931819›Full record

ArticleCirculation research2025

SMC Abca1 and Abcg1 Deficiency Enhances Urinary Bladder Distension but Not Atherosclerosis.

Benedek Halmos, Anouk M La Rose, Daisey Methorst, Anouk G Groenen, Dalibor Nakládal, Venetia Bazioti, Mirjam H Koster, Niels J Kloosterhuis, Azuwerus van Buiten, Elisabeth M Schouten and 14 more

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In one paragraph

Article in Circulation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Benedek Halmos *Department of Pediatrics (B.H., A.M.L.R., D.M., A.G.G., V.B., M.H.K., N.J.K., N.C.A.H., M.L.-M., L.B., S.M.D.N., A.d.B., F.K., M.W.), University Medical Center Groningen, University of Groningen, the Netherlands.ORCID 0000-0002-6010-5096
Anouk M La Rose *Department of Pediatrics (B.H., A.M.L.R., D.M., A.G.G., V.B., M.H.K., N.J.K., N.C.A.H., M.L.-M., L.B., S.M.D.N., A.d.B., F.K., M.W.), University Medical Center Groningen, University of Groningen, the Netherlands.
Daisey MethorstDepartment of Pediatrics (B.H., A.M.L.R., D.M., A.G.G., V.B., M.H.K., N.J.K., N.C.A.H., M.L.-M., L.B., S.M.D.N., A.d.B., F.K., M.W.), University Medical Center Groningen, University of Groningen, the Netherlands.ORCID 0009-0008-9827-5307
Anouk G GroenenDepartment of Pediatrics (B.H., A.M.L.R., D.M., A.G.G., V.B., M.H.K., N.J.K., N.C.A.H., M.L.-M., L.B., S.M.D.N., A.d.B., F.K., M.W.), University Medical Center Groningen, University of Groningen, the Netherlands.ORCID 0000-0002-2573-8701
Dalibor NakládalDepartment of Clinical Pharmacy and Pharmacology (D.N., A.v.B., H.B., L.E.D., R.H.H.), University Medical Center Groningen, University of Groningen, the Netherlands.ORCID 0000-0003-0900-0130
Venetia BaziotiDepartment of Pediatrics (B.H., A.M.L.R., D.M., A.G.G., V.B., M.H.K., N.J.K., N.C.A.H., M.L.-M., L.B., S.M.D.N., A.d.B., F.K., M.W.), University Medical Center Groningen, University of Groningen, the Netherlands.
Mirjam H KosterDepartment of Pediatrics (B.H., A.M.L.R., D.M., A.G.G., V.B., M.H.K., N.J.K., N.C.A.H., M.L.-M., L.B., S.M.D.N., A.d.B., F.K., M.W.), University Medical Center Groningen, University of Groningen, the Netherlands.ORCID 0000-0001-6312-3321
Niels J KloosterhuisDepartment of Pediatrics (B.H., A.M.L.R., D.M., A.G.G., V.B., M.H.K., N.J.K., N.C.A.H., M.L.-M., L.B., S.M.D.N., A.d.B., F.K., M.W.), University Medical Center Groningen, University of Groningen, the Netherlands.ORCID 0009-0000-5500-3282
Azuwerus van BuitenDepartment of Clinical Pharmacy and Pharmacology (D.N., A.v.B., H.B., L.E.D., R.H.H.), University Medical Center Groningen, University of Groningen, the Netherlands.
Elisabeth M SchoutenDepartment of Cardiology (E.M.S.), University Medical Center Groningen, University of Groningen, the Netherlands.ORCID 0000-0001-9568-5345
Nicolette C A HuijkmanDepartment of Pediatrics (B.H., A.M.L.R., D.M., A.G.G., V.B., M.H.K., N.J.K., N.C.A.H., M.L.-M., L.B., S.M.D.N., A.d.B., F.K., M.W.), University Medical Center Groningen, University of Groningen, the Netherlands.
Miriam Langelaar-MakkinjeDepartment of Pediatrics (B.H., A.M.L.R., D.M., A.G.G., V.B., M.H.K., N.J.K., N.C.A.H., M.L.-M., L.B., S.M.D.N., A.d.B., F.K., M.W.), University Medical Center Groningen, University of Groningen, the Netherlands.ORCID 0009-0008-3559-2516
Laura BongiovanniDepartment of Pediatrics (B.H., A.M.L.R., D.M., A.G.G., V.B., M.H.K., N.J.K., N.C.A.H., M.L.-M., L.B., S.M.D.N., A.d.B., F.K., M.W.), University Medical Center Groningen, University of Groningen, the Netherlands.ORCID 0000-0001-8942-6048
Simon M De NeckDepartment of Pediatrics (B.H., A.M.L.R., D.M., A.G.G., V.B., M.H.K., N.J.K., N.C.A.H., M.L.-M., L.B., S.M.D.N., A.d.B., F.K., M.W.), University Medical Center Groningen, University of Groningen, the Netherlands.ORCID 0009-0005-5348-4541
Alain de BruinDepartment of Pediatrics (B.H., A.M.L.R., D.M., A.G.G., V.B., M.H.K., N.J.K., N.C.A.H., M.L.-M., L.B., S.M.D.N., A.d.B., F.K., M.W.), University Medical Center Groningen, University of Groningen, the Netherlands.ORCID 0000-0001-8579-2649
Hendrik BuikemaDepartment of Clinical Pharmacy and Pharmacology (D.N., A.v.B., H.B., L.E.D., R.H.H.), University Medical Center Groningen, University of Groningen, the Netherlands.
Leo E DeelmanDepartment of Clinical Pharmacy and Pharmacology (D.N., A.v.B., H.B., L.E.D., R.H.H.), University Medical Center Groningen, University of Groningen, the Netherlands.ORCID 0000-0003-1798-8353
Marius C van den HeuvelDepartment of Pathology (M.C.v.d.H.), University Medical Center Groningen, University of Groningen, the Netherlands.ORCID 0000-0001-6985-7107
Folkert KuipersDepartment of Pediatrics (B.H., A.M.L.R., D.M., A.G.G., V.B., M.H.K., N.J.K., N.C.A.H., M.L.-M., L.B., S.M.D.N., A.d.B., F.K., M.W.), University Medical Center Groningen, University of Groningen, the Netherlands.ORCID 0000-0003-2518-737X
Igle Jan de JongDepartment of Urology (I.J.d.J.), University Medical Center Groningen, University of Groningen, the Netherlands.ORCID 0000-0002-3444-5548
Judith C SluimerDepartment of Pathology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, the Netherlands (J.C.S.).ORCID 0000-0002-0269-4582
Helle F JørgensenSection of Cardiorespiratory Medicine, Department of Medicine, University of Cambridge, Cambridge Biomedical Campus, United Kingdom (H.F.J.).ORCID 0000-0002-7909-2977
Robert H HenningDepartment of Clinical Pharmacy and Pharmacology (D.N., A.v.B., H.B., L.E.D., R.H.H.), University Medical Center Groningen, University of Groningen, the Netherlands.
Marit WesterterpDepartment of Pediatrics (B.H., A.M.L.R., D.M., A.G.G., V.B., M.H.K., N.J.K., N.C.A.H., M.L.-M., L.B., S.M.D.N., A.d.B., F.K., M.W.), University Medical Center Groningen, University of Groningen, the Netherlands.ORCID 0000-0003-2230-1659

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSmooth muscle cells (SMCs) regulate blood flow distribution via vasoconstriction mediated by α-ARs (α-adrenergic receptors). Plasma membrane cholesterol accumulation affects α

methodsWe generated mice with SMC-specific

resultsCombined

conclusionsWe uncover a new role of SMC cholesterol efflux pathways in suppressing α

Indexed as

AtherosclerosisATP Binding Cassette Transporter 1ATP Binding Cassette Transporter, Subfamily G, Member 1Myocytes, Smooth MuscleUrinary BladderAnimalsCholesterolMaleMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicReceptors, LDLVasoconstrictionAbca1 protein, mouseABCG1 protein, mouseATP Binding Cassette Transporter 1ATP Binding Cassette Transporter, Subfamily G, Member 1CholesterolReceptors, LDLatherosclerosiscell transdifferentiationcholesterolmyocytes, smooth musclevasoconstriction

Identifiers

PMID39931819
PMCPMC11867804

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