ReviewZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
Role of protein post-translational modifications in unexplained recurrent pregnancy loss.
Review in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Dysregulated post‑translational modifications in granulosa cells drive ovarian dysfunction and potential infertility applications (Review).International journal of molecular medicine · 2026Review
- The interaction between gut microbiota and host DNA methylation in the pathogenesis and therapy of inflammatory bowel disease.Frontiers in microbiology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Unexplained recurrent pregnancy loss (URPL) is a complex pathological condition that poses significant challenges for women of childbearing age. As a critical component of epigenetics, post-translational modifications (PTMs) not only regulate protein expression and enhance its diversity but also modulate interactions between proteins and other molecules. PTMs play an essential role in the onset and progression of URPL. For example, methylation modifications can hinder decidualization and regulate trophoblast migration and invasion. Phosphorylation modifications can balance regulatory T cells (Treg)/T helper 17 cells (Th17), polarize macrophages, alter dendritic cell populations, and promote trophoblast apoptosis. Acetylation modifications can induce trophoblasts autophagy and suppress M2 macrophage polarization. Ubiquitination modifications can modulate trophoblast migration and invasion and disrupt the immune microenvironment. Glycosylation modifications can inhibit trophoblast migration and invasion, while lactylation modifications maintain endometrial receptivity. The role of PTMs in URPL highlights their potential as a research entry point and therapeutic target for this condition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.