ArticleCureus2025
Standardization of a Model of Vertebral Metastasis of Breast Cancer in CD1/Nu/Nu Mice.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
20 authors.
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Abstract
introductionBreast cancer is the leading cause of cancer-related death in Mexico, with high mortality associated with spinal bone metastasis. We propose to standardize a murine model of bone metastasis to study and understand the tumor microenvironment. MATERIALS AND
methodsAn experimental, prospective, longitudinal study was conducted using 18 CD1/Nu/Nu 30g nude mice. Two cell lines, MCF-7 and 4T1, were inoculated, clinical follow-up was performed, and biopsy samples were obtained for histopathological evaluation.
resultsHistopathological evaluation of models inoculated with the MCF-7 cell line showed no tumor development, while inoculation with the 4T1 cell line resulted in tumor development, as evidenced by PET-CT and histopathology, using 5,000 and 1,000 cells, respectively.
conclusionsThe use of this model is proposed for studying the clinical, molecular, and prognostic aspects of breast cancer progression by inoculating 1,000 cells of the 4T1 cell line.
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