ReviewRSC advances2025
Recent advancements in the chemistry of Diels-Alder reaction for total synthesis of natural products: a comprehensive review (2020-2023).
Review in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Recent Advances in the Synthesis of Heterocycles via Diels-Alder Reactions on Chromone Cores.ACS omega · 2026Review
- Diradical Character of Cyclic Allenes Enables Their Thermal (2 + 2) Cycloadditions.Journal of the American Chemical Society · 2026Article
- Stereoselective Higher-Order [10+4]- and [10+6] Cycloadditions Between Two Highly Unsaturated and Ambiphilic π-Addends.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- TridentSynth: a webtool for the retrosynthesis of molecules using chimeric type I polyketide synthases and chemoenzymatic pathways.Nucleic acids research · 2026Article
- A Computational/Experimental Investigation into the Reversibility of [6+4]/[4+2] Cycloadditions with Tropone Derivatives.The Journal of organic chemistry · 2026Article
- Advances of Self-Healing Polymers Incorporated in Perovskite Solar Cells for High Durability.Nano-micro letters · 2026Review
- NMR-Based Structural Analysis of Highly Substituted Pyridines From Kondrat'eva Aza-Diels-Alder Cycloadditions.Magnetic resonance in chemistry : MRC · 2026Article
- The Diels-Alder Reaction as a Key Step in Natural Product Synthesis.Progress in the chemistry of organic natural products · 2026Review
- Thermally Induced Intramolecular Diels-Alder Reaction of Furan-Tethered Methylenecyclopropanes.Molecules (Basel, Switzerland) · 2025Article
- SmIAngewandte Chemie (International ed. in English) · 2025Article
- Tandem synthesis of dihydronaphthalen-1(2RSC advances · 2025Article
- Utilizing the Pentadehydro-Diels-Alder Reaction for Polycyclic Aromatic Compound Synthesis: Diels-Alder-Based Linker Transformation.Molecules (Basel, Switzerland) · 2025Article
- Total syntheses of highly oxidativeBeilstein journal of organic chemistry · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite being discovered nearly a century ago, the Diels-Alder (DA) reaction remains a crucial tool in the total synthesis of natural products. It accommodates a broad range of building blocks with varying complexity and levels of derivatization, allowing the formation of six-membered rings with precise stereochemistry. This, in turn, simplifies the synthesis of core structures found in many natural products. In recent years, modifications to the traditional Diels-Alder reaction have expanded its scope. These modifications include the inverse electron demand Diels-Alder reaction, dehydro Diels-Alder reaction, hetero-Diels-Alder reaction, photoenolization Diels-Alder reaction, asymmetric Diels-Alder reaction, and domino Diels-Alder reaction have been employed to extend the scope of this process in the synthesis of natural products. This review discusses the application of the Diels-Alder reaction in the total synthesis of natural products from 2020 to 2023, along with select methodologies that are inspired by or can be used to synthesize natural products.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.