ArticleFrontiers in nutrition2025
Association between the dietary inflammatory index and depressive symptoms in adults with metabolic syndrome: a cross-sectional study from the NHANES database.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Nonlinear dose-response relationship between dietary inflammatory index and risk of depression: a systematic review and meta-analysis.Frontiers in nutrition · 2025Pooled it
- Evaluating and modifying the PHDI for depression prevention: insights from NHANES 2005-2018.Frontiers in nutrition · 2025Article
- Exploring the Real Mental Experience of Patients with Moyamoya Disease: A Qualitative Analysis.Patient preference and adherence · 2025Article
- The mediating role of body roundness index in the association between dietary inflammatory index and depression: evidence from the US National Health and Nutrition Examination Survey 2007-2023.Frontiers in psychiatry · 2025Article
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Abstract
Objective: The comorbidity of metabolic syndrome (MS) and depressive symptoms has emerged as a growing public health concern, contributing to a substantial global economic burden. The pathogenesis of this comorbidity is thought to be closely linked to inflammation. However, research examining the impact of the Dietary Inflammatory Index (DII) on depressive symptoms in adults with MS remains limited. This study aims to investigate the association between the DII and depressive symptoms in adults with MS, utilizing data from the National Health and Nutrition Examination Survey (NHANES). Methods: This cross-sectional study included 7,553 participants aged 20 and older MS from six cycles of the NHANES (2007-2018). Depressive symptoms were assessed using the Patient Health Questionnaire scores, and dietary information was gathered to calculate the Dietary Inflammatory Index (DII). The association between DII scores and depressive symptoms in individuals with MS was evaluated through multivariable logistic regression analysis, adjusting for relevant covariates. Subgroup analyses and restricted cubic splines (RCS) were performed to explore this relationship further. Results: Among the participants, 907 individuals (12.0%) were identified as having depressive symptoms. After adjusting for all covariates, a positive correlation was observed (OR = 1.09, 95% CI: 1.04-1.14). After adjusting for all covariates, a positive association was observed between DII scores and depressive symptoms (OR = 1.09, 95% CI: 1.04-1.14). Individuals in the highest tertile of DII scores had significantly higher odds of depressive symptoms compared to those in the lowest tertile (OR = 1.36, 95% CI: 1.13-1.65). Subgroup analyses revealed that men were more likely to experience depressive symptoms among adults with MS. The RCS model revealed a nonlinear positive association between DII scores and depressive symptoms in these participants. Conclusion: Our study indicates that the DII is positively correlated with an increased likelihood of depressive symptoms among adults with MS in the United States. These findings align with existing research and necessitate further validation through prospective cohort studies.
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