ReviewOncology reports2025
Role of long noncoding RNAs in the regulation of epithelial‑mesenchymal transition in osteosarcoma (Review).
Review in Oncology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
2 authors.
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Abstract
Osteosarcoma (OS) is one of the most widespread malignant bone tissue tumors. However, its early diagnosis is difficult, leading to poor prognoses. Long noncoding RNA (lncRNA) can serve as a molecular marker for the early diagnosis and treatment of OS. lncRNAs regulate the epithelial‑mesenchymal transition (EMT) process to control the occurrence and progression of OS. The present review summarizes the studies on lncRNA regulation of OS via the EMT process. A search of the PubMed database yielded 93 published articles since January 2015, of which 73 focused on lncRNA regulation of OS via the EMT process. The present review has classified lncRNAs based on their relationship with tumors (promoting or inhibiting), mechanism of action and naming convention. Most lncRNAs promote OS through EMT and act via microRNA sponging. Previous studies have focused on lncRNAs with known functions, antisense lncRNAs and long intergenic noncoding RNAs. The findings indicated that lncRNAs can regulate the EMT process through various mechanisms to control OS progression. Further studies on specific lncRNAs and their underlying mechanisms will provide insights for the development of strategies for the diagnosis, prevention and treatment of OS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.