Evidence map›Paper›PMID 39930793›Full record

ArticleJournal of the American Chemical Society2025

Rh(II) and Chiral Phosphoric Acid Co-catalyzed Selective O-H Insertions for Stereodivergent

Jicheng Wu, Peijing Jia, Hua Tang, Deqin Cai, Weiping Tang

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jicheng WuLachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
Peijing JiaLachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
Hua TangLachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
Deqin CaiLachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
Weiping TangLachman Institute for Pharmaceutical Development, School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.ORCID 0000-0002-0039-3196

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Justine Yang Bruce · 1985 to 2026
$142.6M
Develop Catalytic Methods to Streamline the Assembly of OligosaccharidesU01GM125290 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI TANG, WEIPING · 2017 to 2020
$2.2M
Chemical Synthesis and Biological Application of Carbohydrates and Glycoconjugates - Admin SupplementR35GM148266 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Weiping Tang · 2023 to 2026
$1.8M
NCI NIH HHS P30 CA014520NIGMS NIH HHS R35 GM148266NIGMS NIH HHS U01 GM125290
6 · The paper itself

Abstract

Carbohydrates are synthetically challenging molecules with essential biological functions in all living systems. The selective synthesis and modification of carbohydrates are crucial for investigating their biological functions. Controlling chemo-, regio-, and stereoselectivity is a central theme in carbohydrate synthesis. Achieving the full set of stereoisomers of carbohydrate derivatives would significantly enhance the efficiency of building compound libraries for biological studies and drug discovery. However, the selective functionalization of seemingly identical hydroxyl groups in carbohydrates remains a long-standing challenge in organic chemistry. In carbohydrate synthesis, achieving precise control of both relative configurations in catalyst-controlled reactions that create a new stereocenter presents a significant synthetic challenge. Herein, we developed an efficient method for the stereodivergent

Identifiers

PMID39930793
PMCPMC12016578

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.