Evidence map›Paper›PMID 39930775›Full record

ArticleChemistryOpen2025

Characterization, Antibacterial Evaluation and Computational Study of Synthesized 4,5-bis(Hydroxymethyl)-2-Methylpyridin-3-ol Tetraphenylborate Ion-Pair Complex.

Ahmed H Bakheit, Mohamed H Al-Agamy, Rashad Al-Salahi, Essam Ali, Haitham Alrabiah, Gamal A E Mostafa

Abstract read
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In one paragraph

Article in ChemistryOpen, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ahmed H BakheitDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia.
Mohamed H Al-AgamyDepartment of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia.
Rashad Al-SalahiDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia.
Essam AliDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia.
Haitham AlrabiahDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia.
Gamal A E MostafaDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia.

Funding

King Saud University, Riyadh, Saudi Arabia RSP2025R501
6 · The paper itself

Abstract

The synthesis of 4,5-bis(hydroxymethyl)-2-methylpyridin-3-ol tetraphenylborate complex in water using an anion exchange process yielded more than 76 %. The resulting white complex was obtained and characterized using various spectroscopic and analytical techniques, including ultraviolet, infrared radiation (IR), mass, elemental analysis, and nuclear magnetic resonance (NMR). The antimicrobial activity of the formed ion-associate complex was evaluated. The structural, electrical, and bonding properties of a novel pyridoxine-tetraphenylborate ion-pair complex was explored using B3LYP/6-311G(d,p) DFT simulations. Geometries designed for negative complexation energy showed thermodynamically beneficial complex formation. Reduced density gradient (RDG) analysis and non-covalent interaction (NCI) plots showed that van der Waals forces are essential to complex stability. Quantum Theory of Atoms in Molecules (QTAIM) study detected weak and moderate hydrogen bonds in the complex using bond critical point (BCP) features. These results reveal how molecules form and stabilize the pyridoxine-tetraphenylborate ion-pair complex. To know the interaction between receptors and bioactive chemicals, one must understand the mechanism of the ionic complexes formed between bioactive chemicals and/or organic molecules.

Indexed as

Antibacterial activityCharacterizationComputational studyIon-pair complexNon-covalent interaction (NCI)PyridoxineQuantum Theory of Atoms in Molecules (QTAIM)Reduced density gradient (RDG) analysis

Identifiers

PMID39930775
PMCPMC12128165

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.