Evidence map›Paper›PMID 39930604›Full record

ArticleExperimental dermatology2025

The Inflammatory Landscape of a Whole-Tissue Explant Model of Hidradenitis Suppurativa.

Phoebe E Leboit, Dhara U Patel, Jarish N Cohen, Madison I Moss, Haley B Naik, Ashley E Yates, Hobart W Harris, Daniel M Klufas, Esther A Kim, Isaac M Neuhaus and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Phoebe E LeboitDepartment of Dermatology, University of California, San Francisco (UCSF), San Francisco, California, USA.ORCID https://orcid.org/0009-0005-9426-1133
Dhara U PatelDepartment of Dermatology, University of California, San Francisco (UCSF), San Francisco, California, USA.
Jarish N CohenDepartment of Dermatology, University of California, San Francisco (UCSF), San Francisco, California, USA.ORCID https://orcid.org/0000-0002-6043-2177
Madison I MossAlbert Einstein College of Medicine, Bronx, New York, USA.
Haley B NaikDepartment of Dermatology, University of California, San Francisco (UCSF), San Francisco, California, USA.
Ashley E YatesDepartment of Dermatology, University of California, San Francisco (UCSF), San Francisco, California, USA.ORCID https://orcid.org/0009-0001-5177-2161
Hobart W HarrisDepartment of Surgery, UCSF, San Francisco, California, USA.
Daniel M KlufasDepartment of Dermatology, University of California, San Francisco (UCSF), San Francisco, California, USA.
Esther A KimDepartment of Surgery, UCSF, San Francisco, California, USA.
Isaac M NeuhausDepartment of Dermatology, University of California, San Francisco (UCSF), San Francisco, California, USA.
Scott L HansenDepartment of Surgery, UCSF, San Francisco, California, USA.
Ryan L KyleSitryx Therapeutics, Oxford, UK.
Matthew KellySitryx Therapeutics, Oxford, UK.
Michael D RosenblumDepartment of Dermatology, University of California, San Francisco (UCSF), San Francisco, California, USA.
Margaret M LoweDepartment of Dermatology, University of California, San Francisco (UCSF), San Francisco, California, USA.

Funding

Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERMAN, MICHAEL S · 2003 to 2019
$21.8M
Restoring Immune Balance in Hiddradenitis SuppurativaR01AR075864 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSENBLUM, MICHAEL DAVID · 2020 to 2024
$3.5M
NIAMS NIH HHS R01 AR075864NIDDK NIH HHS P30 DK063720NIH HHSSitryx Therapeutics
6 · The paper itself

Abstract

Hidradenitis suppurativa (HS) is a relatively common and highly morbid inflammatory skin disease. Due to the relatively limited understanding of HS's pathogenesis, there are currently insufficient treatment options available, and many patients' medical needs are not being met. This is partly due to the historical scarcity of ex vivo assays and animal models that accurately recapitulate the disease. Thus, we have developed a standardised whole-tissue explant model of HS to examine its pathogenic mechanisms and the efficacy of potential treatments within intact human tissue. We measured cytokine protein and RNA within whole tissue maintained in an agar-media solution, finding that IL-6 and IL-8 concentrations trended upwards in both HS explants and healthy controls, while IL-17A, IL-1β, and TNF-α exhibited increases in HS tissue alone. We also show that the explants were responsive to treatment with both dexamethasone and IL-2. Not only do our results show that this model effectively delivers treatments throughout the explants, but they also elucidate which cytokines are related to the explant process regardless of tissue state and which are related to HS tissue specifically, laying the groundwork for future implementations of this model.

Indexed as

CytokinesHidradenitis SuppurativaDexamethasoneFemaleHumansInflammationInterleukin-17Interleukin-1betaInterleukin-2Interleukin-6Interleukin-8MaleTissue Culture TechniquesTumor Necrosis Factor-alphaCytokinesDexamethasoneIL17A protein, humanInterleukin-17Interleukin-1betaInterleukin-2Interleukin-6Interleukin-8Tumor Necrosis Factor-alphacytokineexplant modelhidradenitis suppurativaimmunologyinflammation

Identifiers

PMID39930604
PMCPMC11811487

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.