Evidence map›Paper›PMID 39930533›Full record

ArticleBiomarker research2025

BNT162b2 mRNA vaccination affects the gut microbiome composition of patients with follicular lymphoma and chronic lymphocytic leukemia.

Annalisa Chiarenza, Gaia Vertillo Aluisio, Nunziatina Laura Parrinello, Sara Marino, Anna Maria Corsale, Grete Francesca Privitera, MojtabaShekarkar Azgomi, Enrico La Spina, Daniela Cambria, Angelo Curtopelle and 5 more

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Article in Biomarker research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Annalisa Chiarenza *Divisione Di Ematologia, AOU Policlinico Rodolico San Marco, Catania, Italy.
Gaia Vertillo Aluisio *Department of Biomedical and Biotechnological Sciences (BIOMETEC), Section Microbiology University of Catania, Catania, Italy. gaia.vertilloaluisio@phd.unict.it.
Nunziatina Laura ParrinelloDivisione Di Ematologia, AOU Policlinico Rodolico San Marco, Catania, Italy.
Sara MarinoDipartimento Di Chirurgia E Specialità Medico Chirurgiche, Università Degli Studi Di Catania, Catania, Italy.
Anna Maria CorsaleDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy.
Grete Francesca PriviteraDepartment of Clinical and Experimental Medicine, BioinformaticsUnit, University of Catania, Catania, Italy.
MojtabaShekarkar AzgomiDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy.
Enrico La SpinaDipartimento Di Chirurgia E Specialità Medico Chirurgiche, Università Degli Studi Di Catania, Catania, Italy.
Daniela CambriaDipartimento Di Chirurgia E Specialità Medico Chirurgiche, Università Degli Studi Di Catania, Catania, Italy.
Angelo CurtopelleDivisione Di Ematologia, AOU Policlinico Rodolico San Marco, Catania, Italy.
Gaetano IsolaDipartimento Di Chirurgia E Specialità Medico Chirurgiche, Università Degli Studi Di Catania, Catania, Italy.
Cirino BottaDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy.
Francesco Di RaimondoDivisione Di Ematologia, AOU Policlinico Rodolico San Marco, Catania, Italy.
Alessandra Romano *Divisione Di Ematologia, AOU Policlinico Rodolico San Marco, Catania, Italy. alessandra.romano@unict.it.
Maria Santagati *Department of Biomedical and Biotechnological Sciences (BIOMETEC), Section Microbiology University of Catania, Catania, Italy. m.santagati@unict.it.

Funding

Ministero dell'Istruzione e del Merito cod 2022FN7ANE, CUP E53D23001300006Ministero dell'Istruzione e del Merito cod. CINECA 202254FLSB, CUP: E53D23001220006Università di Catania programma ricerca di ateneo UNICT 2020-22 linea 2 cod MICROCOSM
6 · The paper itself

Abstract

backgroundIn both chronic lymphatic leukemia (CLL) and follicular lymphoma (FL) immunotherapy determines B-depletion that leads to temporary suppression of humoral immunity, which is clinically relevant especially during the COVID-19 pandemic, when most patients in the first wave received the BNT162b2 vaccine during anti-neoplastic treatment.

methodsTo capture changes in the immunome and microbiome composition in CLL and FL patients upon mRNA-based vaccination, we designed a prospective, longitudinal study to profile both the humoral and the cellular response after exposure to the BNT162b2 COVID-19 vaccine.

resultsIn both CLL patients and FL patients, the second and third administrations of the BNT162b2 vaccine increased the titer of specific antibodies against SARS-CoV-2. In FL patients, vaccination induced expansion of central memory CD8 + CD57dim CD279 + T cells and reduction of the neutrophil subset myeloid 1 (CD14

conclusionsTaken together, our findings reveal the effect of the BNT162b2 vaccine in shaping the microbiome composition in CLL and FL patients, despite receiving treatment for their underlying active disease, and highlight the importance of a comprehensive analysis of the immunome and microbiome profiling to understand immune function in these cohorts of patients.

Indexed as

Chronic lymphatic leukemiaCOVID-19Follicular lymphomaImmunomeMicrobiome profilingMyeloid compositionVaccination

Identifiers

PMID39930533
PMCPMC11812150

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.