Evidence map›Paper›PMID 39930526›Full record

ArticleInternational journal of retina and vitreous2025

In-clinic vitreous biopsy peel pack technique.

Charles DeBoer, Cindy Zhao, Prithvi Mruthyunjaya, Vinit B Mahajan, Karen M Wai, Steven R Sanislo

Abstract readEditorial
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of retina and vitreous, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Charles DeBoerMolecular Surgery Laboratory, Stanford University, 2452 Watson Court, Palo Alto, CA, 94304, USA. cdeboer@stanford.edu.
Cindy ZhaoDepartment of Ophthalmology, Byers Eye Institute, Stanford University, 2452 Watson Court, Palo Alto, CA, 94304, USA.
Prithvi MruthyunjayaDepartment of Ophthalmology, Byers Eye Institute, Stanford University, 2452 Watson Court, Palo Alto, CA, 94304, USA.
Vinit B MahajanMolecular Surgery Laboratory, Stanford University, 2452 Watson Court, Palo Alto, CA, 94304, USA.
Karen M WaiDepartment of Ophthalmology, Byers Eye Institute, Stanford University, 2452 Watson Court, Palo Alto, CA, 94304, USA.
Steven R SanisloMolecular Surgery Laboratory, Stanford University, 2452 Watson Court, Palo Alto, CA, 94304, USA.

Funding

Stanford Vision Research CoreP30EY026877 · NEI · STANFORD UNIVERSITY · PI TIRIN MOORE · 2017 to 2026
$8.0M
Stanford K12 Clinician-Scientist Career Development ProgramK12EY033745 · NEI · STANFORD UNIVERSITY · PI Jeffrey L Goldberg · 2022 to 2026
$2.6M
Structure and Function of Calpain-5R01EY024665 · NEI · UNIVERSITY OF IOWA · PI MAHAJAN, VINIT B · 2015 to 2019
$1.9M
National Institute of Health R01EY024665NEI NIH HHS K12 EY033745NEI NIH HHS NEI P30-EY026877NEI NIH HHS P30 EY026877NEI NIH HHS R01 EY024665
6 · The paper itself

Abstract

backgroundVitreous biopsy is a common technique used to guide management of acute endophthalmitis and help differentiate between infectious and inflammatory conditions. Currently, in-clinic vitreous biopsy is performed with a 25-gauge needle, without the ability to cut vitreous, potentially leading to reduced diagnostic yield. Recent work demonstrated the ability to perform vitreous biopsy with an off-the-shelf vitreous cutter. However, this was limited by complexity of assembly. Here, a technique using a single peel pack vitrectomy cutter is demonstrated for in-clinic vitreous biopsy.

methodsA 25-gauge vitreous cutter is opened from a peel pack. The drive line is identified, cut to length, and attached to a 10 mL syringe. A 1 mL syringe is attached to the aspiration line. After a trocar is used to place a cannula in the pars plana, the vitreous cutter is introduced into the eye. Cutting is performed by an assistant actuating the 10 mL syringe while the surgeon aspirates from the 1 mL syringe. After sample is collected, antimicrobials are injected if required and the cannula is removed.

resultsA peel pack technique simplifies assembly for an in-clinic vitreous biopsy using a manually actuated cutter.

conclusionWe present a novel, improved, and simplified technique for vitreous tap using a vitreous cutter provided in a single peel pack, actuated by a single syringe with minimal assembly prior to use. This technique may be more accessible for clinicians than prior techniques and does not require a surgical console.

Indexed as

EndophthalmitisOffice-based vitrectomy, Uveitis, Masquerade syndromeVitrectomyVitreous biopsy

Identifiers

PMID39930526
PMCPMC11808987

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.