Evidence map›Paper›PMID 39930478›Full record

SynthesisCritical care (London, England)2025

Pertussis infection in critically ill infants: meta-analysis and validation of a mortality score.

Vladimir L Cousin, Caroline Caula, Jason Vignot, Raphael Joye, Matthieu Blanc, Clémence Marais, Pierre Tissières

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Critical care (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Therapeutic Role of Hydroxyurea in Paediatric Hydroxyurea Pertussis:Sultan Qaboos University medical journal · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Vladimir L Cousin *IHU-PROMETHEUS Comprehensive Sepsis Center and Pediatric Intensive Care, Neonatal Medicine and Emergency, AP-HP Paris Saclay University, Bicêtre Hospital, 78, Rue du Général Leclerc, 94270, Le Kremlin-Bicêtre, France.
Caroline Caula *IHU-PROMETHEUS Comprehensive Sepsis Center and Pediatric Intensive Care, Neonatal Medicine and Emergency, AP-HP Paris Saclay University, Bicêtre Hospital, 78, Rue du Général Leclerc, 94270, Le Kremlin-Bicêtre, France.
Jason VignotIHU-PROMETHEUS Comprehensive Sepsis Center and Pediatric Intensive Care, Neonatal Medicine and Emergency, AP-HP Paris Saclay University, Bicêtre Hospital, 78, Rue du Général Leclerc, 94270, Le Kremlin-Bicêtre, France.
Raphael JoyePediatric Cardiology Unit, Women and Child Department, Geneva University Hospital, Geneva, Switzerland.
Matthieu BlancIHU-PROMETHEUS Comprehensive Sepsis Center and Pediatric Intensive Care, Neonatal Medicine and Emergency, AP-HP Paris Saclay University, Bicêtre Hospital, 78, Rue du Général Leclerc, 94270, Le Kremlin-Bicêtre, France.
Clémence MaraisIHU-PROMETHEUS Comprehensive Sepsis Center and Pediatric Intensive Care, Neonatal Medicine and Emergency, AP-HP Paris Saclay University, Bicêtre Hospital, 78, Rue du Général Leclerc, 94270, Le Kremlin-Bicêtre, France.
Pierre TissièresIHU-PROMETHEUS Comprehensive Sepsis Center and Pediatric Intensive Care, Neonatal Medicine and Emergency, AP-HP Paris Saclay University, Bicêtre Hospital, 78, Rue du Général Leclerc, 94270, Le Kremlin-Bicêtre, France. pierre.tissieres@aphp.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite widespread vaccination programs, pertussis continues circulating within populations and remains a life-threatening infection in infants. While several mortality risk factors have been described, a comprehensive synthesis is lacking. We conducted a meta-analysis of studies investigating mortality risk factors in Pertussis infections and validated those factors in a large cohort.

methodsObservational studies published in English were systematically searched in PubMed, EMBASE, and LiSSa databases from 01/2000 to 06/2024. The search yielded 816 unique citations. The primary outcome was mortality before discharge from the Pediatric Intensive Care Unit (PICU). Two independent reviewers assessed the risk of bias and extracted data. A REML-random effect model was used to calculate pooled prevalence and conduct the analysis. The identified risk factors were subsequently evaluated in a monocentric cohort of patients admitted to a tertiary hospital's PICU for severe pertussis between January 1996 and December 2020. Data analysis was conducted between June and August 2024.

resultsSeventeen studies, including 2,725 patients, met the inclusion criteria. The pooled prevalence of mechanical ventilation, continuous renal replacement therapy, and Extracorporeal Membrane Oxygenation support were 55% (95% CI: 40-70; I

conclusionThis meta-analysis identified a simple yet effective score to assess the severity of pertussis infection in infants admitted to PICU. Accurate risk stratification may enable timely treatment of critically ill patients, potentially improving outcomes.

trial registrationThe study protocol was registered on PROSPERO: CRD42024582057.

Indexed as

Whooping CoughCritical IllnessHumansInfantInfant, NewbornIntensive Care Units, PediatricRisk FactorsBordetella pertussisMalignant pertussisMetanalysisMortality

Identifiers

PMID39930478
PMCPMC11808955

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.