Trial reportBMC oral health2025
Effect of intra-socket application of hyaluronic acid gel on soft and hard tissue healing following impacted mandibular third molars extraction (a randomized controlled clinical trial).
Trial report in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Effect of platelet-rich fibrin on microperfusion during early socket healing: a randomized controlled clinical trial.Clinical oral investigations · 2025Trial
- Hyaluronic Acid-Based Gels and Biomaterial Systems for Oral Wound Healing: Design and Clinical Translation.Gels (Basel, Switzerland) · 2026Review
- Gel Delivery Systems in Dental Medicine: From Controlled Release to Regenerative Applications.Gels (Basel, Switzerland) · 2025Review
- Recent Use of Hyaluronic Acid in Dental Medicine.Materials (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOne of the most frequent dental operations is the surgical extraction of an impacted third molar. The study aimed to evaluate the impact of the intra-socket application of 0.8% Hyaluronic Acid (HA) gel on hard & soft tissue healing after surgical removal of the impacted 3rd molar.
objectiveMATERIALS AND
methodsThis randomized controlled clinical study included thirty patients aged from 21-36 years who were scheduled for surgical removal of impacted mandibular third molar. 0.8% hyaluronic acid gel (HA group) was applied immediately after surgery in the intra-socket of 15 patients, and nothing (No HA group) was applied to the socket of the other 15 patients. Soft tissue healing was assessed after extraction on the third, seventh, and fourteenth day. Bone healing was assessed 2 months post-extraction by measuring bone density and socket length from cone beam computerized tomography.
resultsThe soft tissue healing index was significantly better (very good or excellent) in the HA group compared with no HA group after fourteen days postoperative (p < .001). Also, the percentage increase of bone density in the HA group was statistically significantly higher after two months than in the no HA group ((p < .001).
conclusionHyaluronic acid 0.8% gel application improves soft tissue healing and bone density healing following surgical extraction of the mandibular third molar. It could be considered a valuable material for improving bone healing and soft tissue.
trial registrationThe trial is retrospectively registered at the Pan African Clinical Trial Registry with the identification number for the registry PACTR202407576478340 on 30/07/2024.
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