ReviewReproductive biology and endocrinology : RB&E2025
The role of LH in follicle development: from physiology to new clinical implications.
Review in Reproductive biology and endocrinology : RB&E, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Platelet-rich plasma and folliculogenesis: a systematic mechanistic review and computational pathway analysis.Frontiers in reproductive health · 2026Pooled it
- Age-related succession of the gut microbiome drives ovarian function decline in laying hens.Poultry science · 2026Article
- "Extended ovarian stimulation": a prolonged ovarian exposure to gonadotrophins leads to an increase in the oocyte yield-evidence from the DuoStim experience.Journal of assisted reproduction and genetics · 2026Review
- Recombinant LH supplementation during ovarian stimulation modulates early embryo morphokinetics without affecting IVF outcomes in normal responders: a retrospective time-lapse study.Journal of assisted reproduction and genetics · 2026Article
- Delayed ovulation in cattle: Physiological mechanisms, diagnostic approaches, and reproductive management strategies.Veterinary world · 2026Article
- Extracellular Matrix Remodeling and Matrix Metalloproteinases in Ovarian Function and Infertility.International journal of molecular sciences · 2026Review
- Lipid remodeling and circulating semaphorin 3A in diminished ovarian reserve.Scientific reports · 2026Article
- Management of infertility in women with hypothalamic hypogonadotropic hypogonadism: an expert opinion.Reproductive biology and endocrinology : RB&E · 2026Review
- Gestational exposure to the artificial sweetener erythritol reprograms ovarian function through AMH suppression and oxidative stress-mediated disruption of autophagy and PI3K signaling.Frontiers in endocrinology · 2026Article
- Luteinizing hormone supplementation and cumulative live birth rate in assisted reproductive technology cycles among women of advanced reproductive age.Frontiers in endocrinology · 2026Article
- Editorial: Advances on molecular mechanisms regulating reproduction - from gametogenesis to fertilization.Frontiers in molecular biosciences · 2026Article
- Effect of basal LH levels on pregnancy outcome after IVF/ICSI fresh embryo transfer in patients of different ages: a retrospective study.Frontiers in endocrinology · 2026Article
- Unraveling the multifactorial pathophysiology of polycystic ovary syndrome: exploring lifestyle, prenatal influences, neuroendocrine dysfunction, and post-translational modifications.Molecular biology reports · 2025Review
- The Impact of Lifestyle on Reproductive Health: Microbial Complexity, Hormonal Dysfunction, and Pregnancy Outcomes.International journal of molecular sciences · 2025Review
- Reproductive Challenges in Ruminants Under Heat Stress: A Review of Follicular, Oocyte, and Embryonic Responses.Animals : an open access journal from MDPI · 2025Review
- Mechanisms of programmed cell death in livestock follicular development and atresia: a review.Journal of animal science and biotechnology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The process of follicle development is closely regulated by two pituitary gonadotropins: follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Traditionally, folliculogenesis is considered to be divided into a gonadotropin-independent phase and a gonadotropin-dependent phase. Despite this, recent evidence has demonstrated that functional LH receptors are expressed even in smaller follicles during the phase considered to be gonadotropin independent. Luteinizing hormone promotes androgen synthesis within ovarian follicles and seems to significantly contribute to accelerate and enhance the transition from the primordial to the antral stage of folliculogenesis. Thus, LH could play a fundamental role in determining the number of recruitable antral follicles, with a direct impact on the cyclic recruitment of follicles and reproductive potential. Common clinical conditions of pituitary suppression such as hypogonadotropic hypogonadism, other than pregnancy and combined oral contraceptive use, have been considered to analyze the effect of lower serum LH levels on the functional ovarian reserve. This review outlines recent findings on the mechanisms of human follicle development, based on human and animal models, with a direct focus on possible new clinical applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.