ArticleBMC plant biology2025
Coordinated gene expression and hormonal fluxes dictating ginsenoside Rb3 biosynthesis in floral development of Panax notoginseng.
Article in BMC plant biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Insights into Enzymes Involved in the Biosynthesis of Protopanaxadiol-Type Ginsenosides inACS omega · 2026Review
- Multi-omics dissection of metabolic and transcriptional regulation underlying fruit maturation in Panax ginseng.BMC plant biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundPanax notoginseng (PN) is a medicinal plant containing essential ginsenosides. Given the therapeutic significance of ginsenosides, we delved into the mechanisms of ginsenoside Rb3 biosynthesis in PN flowers. We examined this process from the pre-differentiation stage to the end of flowering, aiming to uncover the biochemical pathways underlying ginsenoside production in PN.
resultsBudding stage (T2) was found critical for enhanced Rb3 production. Transcriptomic analysis revealed a marked shift in gene expression beginning at T2, with upregulation in pathways associated with secondary metabolite production. Gene set enrichment analysis (GSEA) illuminated the upregulation of genes involved in terpenoid backbone biosynthesis, amino acid degradation, and terpenoid modifications, specifically at T2. We correlated the fluctuating hormone levels with the activity of the transcription factor MYC2 to underscore hormonal influence on ginsenoside biosynthesis. Biosynthesis pathway reconstruction revealed the dominance of the mevalonate pathway. Critical enzymes such as ACAT, PPDS, DDS, and LUP4 were vital in precursor biosynthesis and modification. Notably, key genes such as HMGCS, FDPS, and DDS, as well as transcription factors MYC2, MYB124, and MYB61.1, showed a concerted surge in activity at T2.
conclusionsThese findings provide insights into the complex gene networks and molecular pathways that regulate ginsenoside biosynthesis, thereby promoting the medicinal properties of PN.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.