ArticleBMC infectious diseases2025
Sources and clinical characteristics of infant pertussis in China: increasing contribution of siblings.
Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Early detection of pertussis related activity by wastewater surveillance ofEmerging microbes & infections · 2026Article
- Effectiveness and safety of 2-month versus 3-month pertussis vaccination initiation and the impact of dosing timeliness: a population-based birth cohort study in China.BMC public health · 2026Article
- Severe Pertussis During Early Infancy from a High-Altitude Region: Two Clinical Cases and Literature Review.Journal of clinical medicine · 2026Article
- Preliminary epidemiological and clinical profile of the 2024 pediatric pertussis outbreak: a retrospective analysis.Frontiers in pediatrics · 2026Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundWhile parents were traditionally the main reservoir for infant pertussis, transmission sources may have shifted with China's multi-child policy. Our study aimed to investigate the household transmission patterns and clinical characteristics of pertussis in infants.
methodsWe investigated infant pertussis patients (aged ≤ 6 months) diagnosed at a hospital (Children's Hospital of Zhejiang University School of Medicine) from 1 January to 1 May 2024. The laboratory diagnosis of pertussis was confirmed through bacterial culture. We collected basic and clinical information and conducted a telephone survey to investigate the transmission patterns within their households.
resultsA total of 275 infant pertussis cases were identified, including 162 (58.9%) infants aged ≤ 3 months. A total of 188 households completed the transmission pattern survey, of which 121 households had two or more children. The clinical characteristic analysis indicated that infants aged ≤ 3 months had more severe disease, with higher proportion of paroxysmal cyanosis (12.4% vs. 3.5%), elevated leukocyte count (13.3 vs. 9.8 × 10
conclusionsThis study highlights the growing involvement of older children in the spread of pertussis, with siblings emerging as the main sources of pertussis transmission to infants in multi-child households. Optimization of pertussis vaccination tactics is advised to protect infants better.
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