Trial reportBMC anesthesiology2025
Effect of remimazolam besylate on elderly patients with mechanical ventilation: a single-center randomized controlled study.
Trial report in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effects of remimazolam and propofol on delirium following anesthesia and sedation in elderly patients: a systematic review and meta-analysis.BMC anesthesiology · 2025Pooled it
- Short-term light sedation with remimazolam besylate versus propofol in the ICU (SHOSREB): a multicentre, randomized, single-blind, controlled trial.Intensive care medicine · 2026Trial
- Article
- Efficacy and safety of remimazolam besylate in patients receiving mechanical ventilation: A randomized phase Ⅱa trial.Journal of intensive medicine · 2026Article
- Safety and efficacy of remimazolam in critical illness.Journal of intensive care · 2026Review
- Prolonged infusion of remimazolam in surgical and medical intensive care unit patients: a pilot pharmacokinetic study.Journal of intensive care · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
objectiveTo compare the clinical prognosis and offline strategy differences between remimazolam besylate and propofol for sedation in elderly patients undergoing mechanical ventilation.
methodsThis single-center prospective randomized controlled study included elderly patients requiring invasive mechanical ventilation in the Emergency Intensive Care Unit (EICU) at The Second Hospital & Clinical Medical School of Lanzhou University from October 2021 to October 2023. Patients were randomly assigned to the remimazolam group (experimental) or propofol group (control) using respective sedation treatments. Clinical treatments remained uninfluenced. After improvement and meeting offline conditions, a cluster offline strategy guided evaluation and treatment. Data on patient demographics, vital signs, clinical outcomes, and adverse events were recorded.
resultsThere were no significant differences in invasive mechanical ventilation time (107.50 vs. 104.50 h, P = 0.969), ICU stay (7 days for both groups, P = 0.603), in-hospital mortality (22.5% vs. 15.0%, P = 0.39), or 28-day survival rate (69.57% vs. 69.23%, P = 0.98) between the control and experimental groups. Tracheotomy was performed in 5 control group patients and 2 experimental group patients (P = 0.235). Sedation-related delirium rates were 7.5% (control) and 5.0% (experimental) (P = 0.613).
conclusionsRemimazolam besylate and propofol showed no significant differences in safety or effectiveness for elderly patients undergoing mechanical ventilation when using the clustered offline strategy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.