Evidence map›Paper›PMID 39930298›Full record

ArticleJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2025

Proteomic Analysis of Chronic Binge Alcohol-Induced Hippocampal and Anterior Cingulate Cortex Neuroadaptations in Simian Immunodeficiency Virus (SIV)-Infected Female Rhesus Macaques.

Taylor Fitzpatrick-Schmidt, Amirsalar Mansouri, Jiri Adamec, Jennifer Klein, Larry Coleman, Kimberly N Edwards, Liz Simon, Patricia E Molina, Michael C Salling, Scott Edwards

Abstract read
In one paragraph

Article in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Taylor Fitzpatrick-SchmidtDepartment of Physiology, LSU Health-New Orleans, 1901 Perdido St. MEB 7205, New Orleans, LA, 70112, USA.
Amirsalar MansouriProteomics Core, LSU Health-New Orleans, New Orleans, USA.
Jiri AdamecProteomics Core, LSU Health-New Orleans, New Orleans, USA.
Jennifer KleinProteomics Core, LSU Health-New Orleans, New Orleans, USA.
Larry ColemanComprehensive Alcohol-HIV/AIDS Research Center, LSU Health-New Orleans, New Orleans, USA.
Kimberly N EdwardsDepartment of Physiology, LSU Health-New Orleans, 1901 Perdido St. MEB 7205, New Orleans, LA, 70112, USA.
Liz SimonDepartment of Physiology, LSU Health-New Orleans, 1901 Perdido St. MEB 7205, New Orleans, LA, 70112, USA.
Patricia E MolinaDepartment of Physiology, LSU Health-New Orleans, 1901 Perdido St. MEB 7205, New Orleans, LA, 70112, USA.
Michael C SallingAlcohol & Drug Abuse Center of Excellence, LSU Health-New Orleans, New Orleans, USA.
Scott EdwardsDepartment of Physiology, LSU Health-New Orleans, 1901 Perdido St. MEB 7205, New Orleans, LA, 70112, USA. sedwa5@lsuhsc.edu.

Funding

Translational Research/Education ComponentP60AA009803 · NIAAA · LSU HEALTH SCIENCES CENTER · PI PATRICIA E. MOLINA · 2004 to 2026
$42.6M
BIOMEDICAL ALCOHOL RESEARCH TRAINING PROGRAMT32AA007577 · NIAAA · LSU HEALTH SCIENCES CENTER · PI PATRICIA E. MOLINA · 1999 to 2026
$9.6M
Vasopressin Signaling in Pain and Alcohol DependenceR01AA025996 · NIAAA · LSU HEALTH SCIENCES CENTER · PI EDWARDS, SCOTT · 2018 to 2022
$1.7M
Medical Student Alcohol Research Internship (MSARI)T35AA021097 · NIAAA · LSU HEALTH SCIENCES CENTER · PI Scott Edwards, PATRICIA E. MOLINA · 2012 to 2026
$471k
Interactions of Alcohol and Pain in the Context of HIVF30AA030941 · NIAAA · LSU HEALTH SCIENCES CENTER · PI Taylor Fitzpatrick-Schmidt · 2023 to 2026
$199k
NIAAA NIH HHS F30 AA030941NIAAA NIH HHS P60 AA009803NIAAA NIH HHS R01 AA025996NIAAA NIH HHS T32 AA007577NIAAA NIH HHS T35 AA021097NIH HHS F30AA030941NIH HHS P60AA009803NIH HHS R01AA025996
6 · The paper itself

Abstract

Human immunodeficiency virus (HIV) infection produces neurological comorbidities including HIV-associated neurocognitive disorder (HAND) and chronic pain. HIV also increases the risk of developing an alcohol use disorder (AUD). With the rising prevalence of AUD in women and people with HIV (PWH), understanding the neurobiological impact of alcohol in these populations is important. We examined proteomic alterations in the hippocampus and anterior cingulate cortex (ACC), brain regions critical for cognition and affective pain, in a female rhesus macaque model of chronic binge alcohol administration and SIV infection. Adult female rhesus macaques received either chronic binge alcohol (CBA, 13-14 g/kg/week of alcohol) or water (VEH) via gastric catheter. All animals were inoculated with simian immunodeficiency virus (SIV

Indexed as

Binge DrinkingGyrus CinguliHippocampusProteomicsSimian Acquired Immunodeficiency SyndromeAnimalsEthanolFemaleMacaca mulattaSimian Immunodeficiency VirusEthanolAlcoholAnterior cingulate cortexCognitionHippocampusProteomicsSimian immunodeficiency virus

Identifiers

PMID39930298
PMCPMC12085871

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.