Evidence map›Paper›PMID 39930295›Full record

ArticleActa neurologica Belgica2025

Magnetic resonance spectroscopy for discriminating primary angiitis of the central nervous system from gliomas and lymphomas.

Ping Lu, Lingyun Cui, Lulin Zhang, Huabing Wang, Linlin Yin, Decai Tian, Xinghu Zhang

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Article in Acta neurologica Belgica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ping LuCenter for Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Lingyun CuiCenter for Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Lulin ZhangCenter for Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Huabing WangCenter for Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Linlin YinCenter for Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Decai TianCenter for Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China.
Xinghu ZhangCenter for Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China. xhzhtiantan@hotmail.com.

Funding

Beijing Natural Science Foundation 7212030, 7212029Beijing Natural Science Foundation grant JQ23027National Natural Science Foundation of China 82271374
6 · The paper itself

Abstract

objectiveConventional imaging often struggles to differentiate between primary angiitis of the central nervous system (PACNS) and intracranial tumors. This study aims to evaluate the application value of proton magnetic resonance spectroscopy (

methodsThis study collected data from 10 patients with PACNS and 15 patients with intracranial tumors (10 gliomas and 5 lymphomas) confirmed by pathological biopsy. The levels of choline (Cho), creatine (Cr), and N-acetylaspartate (NAA) in the lesion areas and contralateral normal brain tissue were measured and analyzed using

resultsCompared to contralateral normal brain tissue, significant differences were observed in the ratios of Cho/Cr, NAA/Cr, and Cho/NAA between the lesion areas of PACNS and intracranial tumors (P < 0.001). After correcting for the corresponding normal brain tissue spectra, the NAA/Cr ratio in PACNS lesion areas was significantly higher than in intracranial tumor lesions (0.90 vs. 0.25, P < 0.001), and the Cho/NAA ratio was significantly lower in PACNS lesions (1.98 vs. 9.00, P < 0.001), while the difference in Cho/Cr was not significant (1.59 vs. 1.94, P = 0.405). When the corrected NAA/Cr ratio was ≥ 0.71, the ROC-AUC for diagnosing PACNS was 1.00, with both specificity and sensitivity at 100%. The subgroup analysis of glioma/lymphoma yielded similar results.

conclusionThe ratios of NAA/Cr and NAA/Cho are significantly meaningful in differentiating PACNS from intracranial tumors, and

Indexed as

GliomaLymphomaMagnetic Resonance ImagingMagnetic Resonance SpectroscopyAdultBrain NeoplasmsFemaleHumansMaleMiddle AgedCentral nervous system lymphomaGliomaPrimary angiitis of the central nervous systemProton magnetic resonance spectroscopy

Identifiers

PMID39930295

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