Evidence map›Paper›PMID 39930243›Full record

ArticleAdvances in experimental medicine and biology2025

Uncovering Novel Drugs that Restore Vision Using Orthogonal Pooling in Zebrafish.

Justine O'Brien, Patrizia Colucci, Yolanda Alvarez, Breandán N Kennedy

Abstract read
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In one paragraph

Article in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Justine O'BrienUCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland.
Patrizia ColucciUCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland.
Yolanda AlvarezUCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland.
Breandán N KennedyUCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland. brendan.kennedy@ucd.ie.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photoreceptor and retinal pigment epithelium (RPE) dysfunction in inherited retinal degenerations (IRDs) and age-related macular degeneration (AMD) necessitate innovative therapies to preserve vision. Vision impairment incurs a substantial global economic burden, with the World Health Organization reporting an annual global productivity loss of approximately $411 billion. Current treatments are limited, underscoring the urgency for novel solutions. Leveraging new screening techniques, novel drugs restoring vision can be uncovered. Here, a workflow is described utilising orthogonal pooling to screen randomised library compounds for drug hits restoring vision and assessing the optokinetic response (OKR) in the atp6v0e1

Indexed as

Drug DiscoveryRetinal DegenerationVision, OcularAnimalsAnimals, Genetically ModifiedDisease Models, AnimalDrug Evaluation, PreclinicalHumansNystagmus, OptokineticZebrafishZebrafish ProteinsZebrafish ProteinsDrug discoveryFirst-in-class drugsGene agnostic approachesOptokinetic responseOrthogonal poolingRandomised library screeningRetinal and macular degenerationZebrafish

Identifiers

PMID39930243

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.