ReviewAdvances in experimental medicine and biology2025
Key Claudins at the Blood-Retina Barriers.
Review in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Tight junction structure, assembly and (dys)function.Nature reviews. Molecular cell biology · 2026Review
- Dysregulation of neurovascular unit in the retina after optic nerve injury.BMC ophthalmology · 2026Article
- Long non-coding RNA SNHG17 contributes to proliferation and migration of retinal vascular endothelial cell in diabetic retinopathy through miR-34a-5p/CDK6 axis.BMC ophthalmology · 2026Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tight junctions are physical barriers that limit the paracellular diffusion of solutes and ions. The blood-retina barriers are cellular barriers composed of tight junctions established in retinal pigment epithelial (RPE) cells and retinal endothelial cells to maintain retinal homeostasis. Claudins are the major components of tight junctions, and their dysregulation leads to impaired blood-retina barrier integrity, resulting in retinal diseases with concomitant local inflammation. In this chapter, we introduce two important claudins, claudin-5 and -19, and briefly explain how decreased expression of these claudins is associated with the progress of diabetic retinopathy (DR) and age-related macular degeneration (AMD) by compromising the blood-retina barriers.
Indexed as
Identifiers
39930236What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.