Evidence map›Paper›PMID 39930235›Full record

ReviewAdvances in experimental medicine and biology2025

Role of Primary Cilia in the Eye.

Dominik Reichert, Ruchi Sharma, Helen May-Simera, Kapil Bharti

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dominik ReichertOcular and Stem Cell Translational Research Section, National Eye Institute, Bethesda, MD, USA.
Ruchi SharmaOcular and Stem Cell Translational Research Section, National Eye Institute, Bethesda, MD, USA.
Helen May-SimeraInstitute of Molecular Physiology, Johannes Gutenberg Universität, Mainz, Germany.
Kapil BhartiOcular and Stem Cell Translational Research Section, National Eye Institute, Bethesda, MD, USA. kapil.bharti@nih.gov.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary cilia are evolutionarily conserved organelles that regulate various aspects of cell development, differentiation, and function. Defects in primary cilia lead to diseases known as ciliopathies, with vision loss as one of the most frequent manifestations. Increasing evidence suggests that in addition to the connecting cilium of photoreceptors in the retina, ciliary defects in other ocular tissues contribute toward the vision loss phenotype seen in ciliopathy patients. This review explores the current literature on the role of primary cilia in the anterior chamber, including the cornea, trabecular meshwork, iris, and ciliary body, and in retinal non-photoreceptor cells, and retinal pigment epithelium.

Indexed as

CiliaEyeAnimalsCiliary BodyCiliopathiesHumansRetinal Pigment EpitheliumTrabecular MeshworkAnterior chamberCiliopathiesEye developmentPrimary ciliaRetinaRetinal degenerationRPE

Identifiers

PMID39930235

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.