Evidence map›Paper›PMID 39930225›Full record

ReviewAdvances in experimental medicine and biology2025

Mitochondrial DNA Damage in the Retinal Pigmented Epithelium (RPE) and Its Role in RPE Pathobiology.

Raela B Ridley, Ashley C Amontree, Alfred S Lewin, Cristhian J Ildefonso

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Raela B RidleyDepartment of Ophthalmology, University of Florida College of Medicine, Gainesville, FL, USA.
Ashley C AmontreeDepartment of Ophthalmology, University of Florida College of Medicine, Gainesville, FL, USA.
Alfred S LewinDepartment of Molecular Genetics & Microbiology, University College of Medicine, Gainesville, FL, USA.
Cristhian J IldefonsoDepartment of Ophthalmology, University of Florida College of Medicine, Gainesville, FL, USA. ildefons@ufl.edu.

Funding

RESEARCH TRAINING IN VISION SCIENCET32EY007132 · NEI · UNIVERSITY OF FLORIDA · PI W CLAY SMITH · 1991 to 2026
$3.8M
Core Equipment for Assessment of Ocular Disease in Animal ModelsS10OD028476 · OD · UNIVERSITY OF FLORIDA · PI SMITH, W CLAY · 2020 to 2020
$348k
NEI NIH HHS T32 EY007132NIH HHS S10 OD028476
6 · The paper itself

Abstract

Retinal pigmented epithelial (RPE) cells have critical functions in the retina. These cells rely heavily on their mitochondria to generate energy, offer metabolites for biosynthesis through the TCA cycle, regulate apoptosis, and process lipids from photoreceptors. Therefore, mitochondrial damage has significant consequences for the RPE and, by proxy, photoreceptors. Researchers have identified damaged mitochondrial DNA (mtDNA) accumulation in patient samples from aged and diseased individuals. These damages include point mutations and complete deletions of mtDNA segments. The most significant observation in these studies is a positive correlation between the accumulation of damaged mtDNA with the stage of AMD rather than aging. This chapter will discuss how mitochondrial dysfunction in the RPE can drive disease pathobiology by altering their physiological functions.

Indexed as

DNA DamageDNA, MitochondrialMacular DegenerationMitochondriaRetinal Pigment EpitheliumAnimalsHumansDNA, MitochondrialAge-related macular degenerationDNA repairMitochondriaRetina pigmented epitheliumSenescence

Identifiers

PMID39930225

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.