Evidence map›Paper›PMID 39930221›Full record

ReviewAdvances in experimental medicine and biology2025

The Importance of Differentiated RPE Cultures for studying Cell Biological Processes.

Roni A Hazim, David S Williams

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Roni A HazimDepartment of Ophthalmology, Stein Eye Institute, University of California, Los Angeles, CA, USA.
David S WilliamsDepartment of Ophthalmology, Stein Eye Institute, University of California, Los Angeles, CA, USA. dswilliams@ucla.edu.

Funding

In-depth molecular studies of dynein transport in the RPEK99EY034576 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HAZIM, RONI · 2023 to 2024
$209k
NEI NIH HHS K99 EY034576
6 · The paper itself

Abstract

The retinal pigment epithelium (RPE) is a polarized monolayer of cells that provides essential functions to the light-sensitive photoreceptors in the retina. Many of the cell biological processes involving the RPE, including those underlying disease mechanisms, can be studied using in vitro culture systems. For such models to be informative, the RPE cultures must be well-differentiated and fully mature, exhibiting the key characteristics of their native counterparts. In this mini review, we emphasize this requirement to use fully differentiated RPE cultures by discussing structural, functional, and metabolic aspects of the RPE.

Indexed as

Cell DifferentiationRetinal Pigment EpitheliumAnimalsCell Culture TechniquesCells, CulturedHumansActin filamentsCytoskeletonMetabolismMicrotubulesPhagocytosisRPE

Identifiers

PMID39930221

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.