Evidence map›Paper›PMID 39930217›Full record

ReviewAdvances in experimental medicine and biology2025

Molecular Components of Vesicle Cycling at the Rod Photoreceptor Ribbon Synapse.

Christin Hanke-Gogokhia, Thomas E Zapadka, Stella Finkelstein, Vadim Y Arshavsky, Jonathan B Demb

Abstract readReview
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In one paragraph

Review in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Christin Hanke-GogokhiaDepartment of Ophthalmology & Visual Science, Yale University School of Medicine, New Haven, CT, USA.
Thomas E ZapadkaDepartment of Cellular & Molecular Physiology, Yale University School of Medicine, New Haven, CT, USA.
Stella FinkelsteinDepartment of Ophthalmology, Duke University School of Medicine, Durham, NC, USA.
Vadim Y ArshavskyDepartment of Ophthalmology, Duke University School of Medicine, Durham, NC, USA.
Jonathan B DembDepartment of Ophthalmology & Visual Science, Yale University School of Medicine, New Haven, CT, USA. jonathan.demb@yale.edu.

Funding

VISION RESEARCHP30EY005722 · NEI · DUKE UNIVERSITY · PI Goldis Malek · 1985 to 2026
$19.3M
Yale Core Grant for Vision ResearchP30EY026878 · NEI · YALE UNIVERSITY · PI Jonathan B Demb · 2016 to 2026
$7.1M
Neural Circuits and Synapses for Early Visual ProcessingR01EY014454 · NEI · YALE UNIVERSITY · PI DEMB, JONATHAN B · 2005 to 2022
$6.7M
Mechanisms of photoreceptor disc maturationR01EY030451 · NEI · DUKE UNIVERSITY · PI ARSHAVSKY, VADIM Y · 2020 to 2024
$2.4M
Visual Science Training GrantT32EY022312 · NEI · YALE UNIVERSITY · PI ZHOU, Z JIMMY · 2012 to 2021
$1.3M
Role of dynamin in photoreceptor disc morphogenesisF32EY032389 · NEI · YALE UNIVERSITY · PI HANKE-GOGOKHIA, CHRISTIN · 2021 to 2023
$221k
Retinal Circuitry Response to Nerve InjuryF31EY034776 · NEI · YALE UNIVERSITY · PI ZAPADKA, THOMAS EUGENE · 2023 to 2025
$146k
NEI NIH HHS F31 EY034776NEI NIH HHS F32 EY032389NEI NIH HHS P30 EY005722NEI NIH HHS P30 EY026878NEI NIH HHS R01 EY014454NEI NIH HHS R01 EY030451NEI NIH HHS T32 EY022312
6 · The paper itself

Abstract

Rod photoreceptors are light-sensitive neurons of the retina that support vision in dim light. A rod cell consists of an outer segment for phototransduction, an inner segment and soma for energy production and protein synthesis, and a synaptic terminal for vesicle release onto second-order neurons-bipolar and horizontal cells. Mouse rods contain a single ribbon synaptic release site, where vesicles filled with glutamate are released at a rate of up to ~20 vesicles/synapse/second. This high release rate requires a fine balance between synaptic vesicle exocytosis and endocytosis. Here, we review the properties of synaptic transmission and highlight proteins essential for synaptic vesicle recycling at the rod ribbon synapse.

Indexed as

Retinal Rod Photoreceptor CellsSynapsesSynaptic TransmissionSynaptic VesiclesAnimalsEndocytosisExocytosisHumansMiceDynaminEndocytosisExocytosisRod photoreceptorsSynaptic ribbonSynaptic transmissionSynaptic vesicles

Identifiers

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.