The PRPH2 D2 Loop: Biochemical Insights and Implications in Disease.

Larissa Ikelle, Muayyad R Al-Ubaidi, Muna I Naash

Abstract readReview

In one paragraph

Review in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Elevating Jak-STAT signaling via SOCS3 deletion sustains photoreceptor viability and visual function in mouse models of retinitis pigmentosa.Cell communication and signaling : CCS · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Larissa IkelleDepartment of Biomedical Engineering, University of Houston, Houston, TX, USA.

Muayyad R Al-UbaidiDepartment of Biomedical Engineering, University of Houston, Houston, TX, USA. malubaid@central.uh.edu.ORCID https://orcid.org/0000-0002-4914-350X

Muna I NaashDepartment of Biomedical Engineering, University of Houston, Houston, TX, USA. mnaash@central.uh.edu.ORCID https://orcid.org/0000-0002-6534-5144

Funding

The differential behavior of Prph2/Rom1 in rods and cone contributes to Prph2-associated disease heterogeneityF31EY033216 · NEI · UNIVERSITY OF HOUSTON · PI IKELLE, LARISSA · 2021 to 2025

$208k

NEI NIH HHS F31 EY033216

6 · The paper itself

Abstract

PRPH2 is a glycosylated tetraspanin protein that plays a crucial role in outer segment morphogenesis. The protein induces membrane curvature at the rim and orchestrates proper disc elaboration by forming a complex network of homo- and hetero-oligomers, primarily mediated through its EC2/D2 loop. This loop, a functionally and structurally essential domain shared by all tetraspanins, is divided into two subdomains responsible for diverse interactions. Pathological mutations in the EC2/D2 loop account for nearly 70% of all PRPH2 mutations, resulting in a spectrum of heterogenous disease phenotypes. In this chapter, we provide an overview of the structural elements of the EC2/D2 loop of PRPH2 and explore the cellular and biochemical consequences of known mutations.

Indexed as

MutationPeripherinsAnimalsHumansProtein DomainsPeripherinsD2 loopEC2Large extracellular loopMacular dystrophyPeripherin-2Retinal degenerationRetinitis pigmentosaRod Outer Segment Membrane Protein 1Tetraspanin

Identifiers

PMID39930215

DOI10.1093/hmg/ddy240

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.