ArticleAdvances in experimental medicine and biology2025
Girdin: A Class I Phosphatidylinositol 3-Kinase-Binding Protein in the Retina.
Article in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Girdin is a nonreceptor guanine nucleotide exchange factor but functions as a guanine nucleotide exchange factor for the G protein Gαi. It plays a crucial role in regulating cell migration and adhesion, as well as protecting cells from apoptosis. Previous research has demonstrated that Girdin activates Akt through a pathway involving phosphatidylinositol 3-kinase (PI3K) in HeLa cells. Our earlier studies revealed that light-induced activation of the PI3K/Akt pathway in the retina is controlled by G-protein-coupled receptor activation, specifically the rhodopsin-dependent insulin receptor. In our current study, we investigated the localization and interaction of Girdin with the p85α-subunit of PI3K. Our findings indicate that Girdin is present in photoreceptor cells and interacts with the p85α-subunit of PI3K in response to light stimulation. Activation of the PI3K/Akt pathway promotes the survival of photoreceptor cells. These results suggest that Girdin might be a novel factor contributing to the protection of photoreceptors in response to light, potentially offering new insights into neuroprotection for these cells.
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