Evidence map›Paper›PMID 39930208›Full record

ArticleAdvances in experimental medicine and biology2025

Stimulation of Thyroid Hormone Signaling Induces Stress Responses in Mouse Retina.

Shujuan Li, Hongwei Ma, Fan Yang, Xi-Qin Ding

Abstract read
PubMed Publisher
In one paragraph

Article in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shujuan LiDepartment of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Hongwei MaDepartment of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Fan YangDepartment of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Xi-Qin DingDepartment of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. xi-qin-ding@ouhsc.edu.

Funding

P30-CENTER CORE GRANT FOR VISION RESEARCHP30EY021725 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Michelle C Callegan, MICHAEL H ELLIOTT · 2011 to 2026
$10.5M
Thyroid Hormone Signaling and Cone Photoreceptor DegenerationR01EY033841 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI DING, XI-QIN · 2022 to 2025
$1.5M
NEI NIH HHS P30 EY021725NEI NIH HHS R01 EY033841
6 · The paper itself

Abstract

Thyroid hormone (TH) signaling is essential for cell proliferation, differentiation, and metabolic homeostasis. In the retina, TH signaling regulates retinal development, cone opsin expression, and photoreceptor viability. Suppressing TH signaling protects photoreceptors in mouse models of retinal degeneration whereas excessive TH signaling induces photoreceptor degeneration in mice. This work examined stress responses in the mouse retina after stimulation of TH signaling. C57BL/6 and Nrl

Indexed as

Oxidative StressRetinaRetinal DegenerationSignal TransductionThyroid HormonesTriiodothyronineAnimalsEpendymoglial CellsMiceMice, Inbred C57BLMice, KnockoutMitochondriaThyroid HormonesTriiodothyronineMitochondrial respirationOxidative stress and damagePhotoreceptorRetinal degenerationRetinal stress responseThyroid hormone

Identifiers

PMID39930208

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.