Deletion of Pnpla2 Causes Malformation and Malperformance of Mouse Photoreceptors.

Alexandra Bernardo-Colón, Lijin Dong, Mones Abu-Asab, S Patricia Becerra

Abstract read

In one paragraph

Article in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alexandra Bernardo-ColónSection of Protein Structure and Function, National Eye Institute, NIH, Bethesda, MD, USA.

Lijin DongGenetic Engineering Core, National Eye Institute, NIH, Bethesda, MD, USA.

Mones Abu-AsabHistopathology Core Facility, National Eye Institute, NIH, Bethesda, MD, USA.

S Patricia BecerraSection of Protein Structure and Function, National Eye Institute, NIH, Bethesda, MD, USA. becerras@nei.nih.gov.

Funding

Role of Protein Interactions in Retina Development and FunctionZIAEY000306 · NEI · NATIONAL EYE INSTITUTE · PI BECERRA, S. PATRICIA · 2009 to 2025

$15.6M

Intramural NIH HHS ZIA EY000306

6 · The paper itself

Abstract

Photoreceptor cells express the patatin-like phospholipase domain-containing 2 (PNPLA2) gene that codes for pigment epithelium-derived factor receptor (PEDF-R). PEDF-R exhibits phospholipase activity that mediates the neurotrophic action of its ligand PEDF. Because phospholipids are the most abundant lipid class in the retina, we investigated the role of PNPLA2 in photoreceptors by generating CRISPR Pnpla2 knockout mouse lines. We aim to characterize one of the two lines of mice generated with global Pnpla2 gene deletion. The retinas of Pnpla2

Indexed as

Gene DeletionLipasePhotoreceptor Cells, VertebrateAnimalsEye ProteinsMiceMice, KnockoutReceptors, NeuropeptideRetinaSerpinsEye ProteinsLipasepigment epithelium-derived factor receptorReceptors, NeuropeptideSerpinsATGLEyePEDF-RPhospholipasePhotoreceptorsPnpla2Retina

Identifiers

PMID39930203

DOI10.1007/978-3-031-76550-6_40

PMCPMC13490977

What OpenQuestion holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.