Evidence map›Paper›PMID 39930201›Full record

ReviewAdvances in experimental medicine and biology2025

The Power of Zebrafish in Disease Modeling and Therapy Discovery for Inherited Retinal Degeneration.

Huanhuan Xiao, Randi Marshall, Meera T Saxena, Liyun Zhang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Ciliary Defects in Inherited Retinal Diseases.Advanced genetics (Hoboken, N.J.) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Huanhuan XiaoDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA.
Randi MarshallDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA.
Meera T SaxenaDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA.
Liyun ZhangDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, USA. lzhang98@jhmi.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the research of inherited retinal degeneration (IRD), zebrafish have emerged as a powerful model system, offering profound insights into disease mechanisms and opening new therapeutic avenues. This mini-review discusses the distinctive advantages that zebrafish provide for investigating retinal degeneration. It outlines contemporary genetic tools, with a specific focus on advanced CRISPR/Cas9 gene targeting technology, utilized for genome manipulation and disease modeling in zebrafish. By emphasizing the pivotal role of zebrafish in large-scale high-throughput drug discovery and the exploration of innovative gene therapy strategies, this succinct review underscores the adaptability and significance of the zebrafish model in advancing IRD research. It establishes a robust foundation for future studies and therapeutic developments in the field.

Indexed as

Disease Models, AnimalGenetic TherapyRetinal DegenerationZebrafishAnimalsCRISPR-Cas SystemsDrug DiscoveryGene EditingHumansCRISPR/Cas9Disease modelDrug discoveryGene therapyInherited retinal degenerationZebrafish

Identifiers

PMID39930201

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.