Evidence map›Paper›PMID 39930197›Full record

ArticleAdvances in experimental medicine and biology2025

Association Between C22:5-Containing Lipids and RPE Pathologies in Mice with Tmem135 Overexpression.

Michael Landowski, Sakae Ikeda, Akihiro Ikeda

Abstract read
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In one paragraph

Article in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Michael LandowskiDepartment of Medical Genetics, University of Wisconsin-Madison, Madison, WI, USA.
Sakae IkedaDepartment of Medical Genetics, University of Wisconsin-Madison, Madison, WI, USA.
Akihiro IkedaDepartment of Medical Genetics, University of Wisconsin-Madison, Madison, WI, USA. aikeda@wisc.edu.

Funding

UW Vision Research Core - Administrative CoreP30EY016665 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI AKIHIRO IKEDA · 2005 to 2026
$12.6M
Molecular Genetics of Age-Dependent Retinal DegenerationR01EY022086 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI AKIHIRO IKEDA · 2012 to 2026
$6.1M
Vision Research Training ProgramT32EY027721 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI ROBERT W NICKELLS · 2018 to 2026
$1.5M
The Function of Transmembrane Protein 135 in Retinal Pigmented EpitheliumF32EY032766 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI LANDOWSKI, MICHAEL · 2021 to 2022
$117k
NEI NIH HHS F32 EY032766NEI NIH HHS P30 EY016665NEI NIH HHS R01 EY022086NEI NIH HHS T32 EY027721
6 · The paper itself

Abstract

Dysregulation of lipid metabolism has been linked with risk for age-related retinal diseases including age-related macular degeneration (AMD). However, how dysregulated lipid metabolism contributes to AMD development is unknown. In this study, we evaluated the retinal and plasma lipidomes of a mouse model displaying retinal pigmented epithelium (RPE) pathologies that are observed in AMD including RPE dysmorphia and degeneration. We found that the RPE phenotypes in mice overexpressing transmembrane protein 135 (Tmem135 TG) are correlated with retinal and plasma lipidome changes. While distinct lipid profiles were observed in the retina and plasma of Tmem135 TG mice, a common finding in both retinal and plasma lipidomes was an increase of lipids containing C22:5. This data suggests that accumulation of C22:5-containing lipids may contribute to the development of the RPE pathologies in Tmem135 TG mice.

Indexed as

Lipid MetabolismLipidsMacular DegenerationMembrane ProteinsRetinal Pigment EpitheliumAnimalsDisease Models, AnimalMiceMice, Inbred C57BLMice, TransgenicLipidsMembrane ProteinsAge-related macular degenerationLipidLipidomicsPhospholipidPlasmaPolyunsaturated fatty acidsRetinaRetinal pigmented epitheliumTransgenic mice

Identifiers

PMID39930197
PMCPMC12107616

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.