Evidence map›Paper›PMID 39930192›Full record

ArticleAdvances in experimental medicine and biology2025

Loss of Usher II Proteins in Mice Does Not Affect Photoreceptor Ultrastructure.

Tylor R Lewis, Sebastien Phan, Carson M Castillo, Keun-Young Kim, Mark H Ellisman, Vadim Y Arshavsky

Abstract read
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In one paragraph

Article in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tylor R LewisDepartment of Ophthalmology, Duke University Medical Center, Durham, NC, USA. tylor.lewis@duke.edu.
Sebastien PhanNational Center for Microscopy and Imaging Research, School of Medicine, University of California San Diego, La Jolla, CA, USA.
Carson M CastilloDepartment of Ophthalmology, Duke University Medical Center, Durham, NC, USA.
Keun-Young KimNational Center for Microscopy and Imaging Research, School of Medicine, University of California San Diego, La Jolla, CA, USA.
Mark H EllismanNational Center for Microscopy and Imaging Research, School of Medicine, University of California San Diego, La Jolla, CA, USA.
Vadim Y ArshavskyDepartment of Ophthalmology, Duke University Medical Center, Durham, NC, USA.

Funding

VISION RESEARCHP30EY005722 · NEI · DUKE UNIVERSITY · PI Vadim Y Arshavsky · 1985 to 2026
$19.3M
Mechanisms of photoreceptor disc maturationR01EY030451 · NEI · DUKE UNIVERSITY · PI ARSHAVSKY, VADIM Y · 2020 to 2024
$2.4M
The role of ADAM9 in retinal health and diseaseR00EY033763 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Tylor Robert Lewis · 2024 to 2026
$747k
The role of ADAM9 in retinal health and diseaseK99EY033763 · NEI · DUKE UNIVERSITY · PI LEWIS, TYLOR ROBERT · 2022 to 2023
$252k
NEI NIH HHS K99 EY033763NEI NIH HHS P30 EY005722NEI NIH HHS R00 EY033763NEI NIH HHS R01 EY030451
6 · The paper itself

Abstract

Usher syndrome is characterized by both vision and hearing loss. Mutations in three genes, USH2A, ADGRV1, and WHRN, lead to Usher syndrome Type II, in which the onset of vision loss usually takes place after puberty. Mouse models of Usher syndrome Type II have an incredibly mild retinal phenotype that typically begins after ~1-2 years of age and, therefore, do not fully represent the pathology in human patients. Both USH2A (also known as Usherin) and ADGRV1 (also known as USH2C or GPR98) are transmembrane proteins containing large extracellular domains. In this study, we questioned whether the relatively mild phenotype of USH2A and ADGRV1 mutant mouse models may arise from a functional redundancy between these two proteins. We generated a double knockout (Ush2a

Indexed as

Extracellular Matrix ProteinsPhotoreceptor Cells, VertebrateReceptors, G-Protein-CoupledUsher SyndromesAnimalsDisease Models, AnimalMiceMice, Inbred C57BLMice, KnockoutAdgrv1 protein, mouseExtracellular Matrix ProteinsReceptors, G-Protein-CoupledUsh2a protein, mouseADGRV1GPR98PhotoreceptorRetinaUSH2AUSH2CUsherUsherinUsher syndrome

Identifiers

PMID39930192

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.