Evidence map›Paper›PMID 39930188›Full record

ReviewAdvances in experimental medicine and biology2025

Role of Microglia in Glaucomatous Pathology.

McKenna M Somerville, Mary Anne Garner, Christopher A Girkin, Alecia K Gross

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Role of store-operated CaFrontiers in aging neuroscience · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

McKenna M SomervilleDepartments of Neurobiology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Mary Anne GarnerDepartments of Neurobiology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Christopher A GirkinDepartments of Ophthalmology and Visual Sciences, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Alecia K GrossDepartments of Neurobiology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. agross@uab.edu.

Funding

Visual Phenotyping CoreP30EY003039 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Paul Douglas Gamlin · 1985 to 2026
$16.9M
The mechanotranscriptome of the optic nerve head following acute experimental ocular hypertension in living human eyesR01EY035053 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Massimo Antonio Fazio, CHRISTOPHER Anthony GIRKIN · 2023 to 2026
$2.2M
NEI NIH HHS P30 EY003039NEI NIH HHS R01 EY035053
6 · The paper itself

Abstract

Glaucoma is a leading cause of irreversible blindness worldwide and is characterized by progressive loss of retinal ganglion cells. Much research has gone into further understanding the pathology of this disease, including the extent to which microglia modulate its pathogenesis. This has revealed a role of the innate immune system in glaucomatous pathology that begins before the onset of retinal ganglion cell dysfunction and degeneration. Stimulation of the innate immune response triggers downstream cascades implicated in chronic disease, making immune pathways invaluable in our understanding of glaucomatous pathology. This review will focus on evidence that supports the role of the microglial immunologic response in the pathogenesis of glaucoma.

Indexed as

GlaucomaImmunity, InnateMicrogliaRetinal Ganglion CellsAnimalsHumansAstrocytesGlaucomaImmune systemInnate immunityMicrobiotaMicrogliaRetinal ganglion cells

Identifiers

PMID39930188
PMCPMC12060067

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.