Evidence map›Paper›PMID 39930182›Full record

ArticleAdvances in experimental medicine and biology2025

Prime Editing Strategy to Install the Mfrp Retinal Degeneration 6 Mutation.

Bruna Lopes da Costa, Jorge Pincay, Scott E Brodie, Stephen H Tsang, Peter M J Quinn

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In one paragraph

Article in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Bruna Lopes da CostaDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.
Jorge PincayJonas Children's Vision Care, and Bernard & Shirlee Brown Glaucoma Laboratory, Department of Ophthalmology, Columbia University, New York, NY, USA.
Scott E BrodieDepartment of Ophthalmology, Columbia University Irving Medical Center, New York, NY, USA.
Stephen H TsangDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.
Peter M J QuinnDepartment of Ophthalmology, Columbia University Irving Medical Center, New York, NY, USA. peter.quinn1@pennmedicine.upenn.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mutations in the MFRP (membrane-type frizzled-related protein) gene are associated with a spectrum of ocular diseases. Here, we report on a patient with MFRP-linked autosomal recessive retinitis pigmentosa (arRP) with nanophthalmos who exhibited yellow deposits circumferentially along with far temporal intraretinal pigment migration. In future studies, we plan to explore the amelioration of MFRP-associated phenotypes in patient-specific induced pluripotent stem cell (iPSC)-derived retinal pigment epithelium and in vivo using the classical Mfrp

Indexed as

Frizzled ReceptorsGene EditingMembrane ProteinsMicrophthalmosMutationRetinitis PigmentosaAnimalsFemaleFrizzled-Related ProteinsHumansInduced Pluripotent Stem CellsMaleMiceRetinal Pigment EpitheliumFrizzled ReceptorsFrizzled-Related ProteinsMembrane ProteinsMFRP protein, humanAutosomal recessive retinitis pigmentosa (arRP)Membrane-type frizzled-related protein (MFRP)Prime editingRetinal degeneration 6 (Rd6)

Identifiers

PMID39930182

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.