Evidence map›Paper›PMID 39930176›Full record

ReviewAdvances in experimental medicine and biology2025

MFRP in Early Onset Retinal Degeneration: Clinical and Molecular Perspectives.

DaNae R Woodard, Radha Ayyagari

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

DaNae R WoodardDepartment of Ophthalmology, Shiley Eye Institute, University of California San Diego, San Diego, CA, USA.
Radha AyyagariDepartment of Ophthalmology, Shiley Eye Institute, University of California San Diego, San Diego, CA, USA. rayyagari@health.ucsd.edu.

Funding

Vision BiostatisticsP30EY022589 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LINDA M ZANGWILL · 2012 to 2026
$10.3M
Molecular Basis of Hereditary Retinal DegenerationsR01EY021237 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AYYAGARI, RADHA · 2011 to 2020
$5.6M
Molecular Mechanisms Underlying Macular DegenerationsR01EY013198 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI AYYAGARI, RADHA · 2001 to 2011
$4.0M
Molecular mechanism underlying late-onset retinal/macular degenerationR01EY030591 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AYYAGARI, RADHA · 2020 to 2023
$1.9M
NEI NIH HHS P30 EY022589NEI NIH HHS R01 EY013198NEI NIH HHS R01 EY021237NEI NIH HHS R01 EY030591
6 · The paper itself

Abstract

The membrane-frizzled related protein (MFRP) is a retinal pigment epithelium (RPE) and ciliary epithelium-expressed gene of unknown function. Interest in MFRP stems from clinical manifestations that range from acute-angle closure glaucoma to microphthalmia and Retinitis pigmentosa in patients with MFRP mutations. Furthermore, the genetic ablation of Mfrp in mice results in an early-onset retinal disease with visible degeneration around 1mo of age and primary rod photoreceptor loss. Yet, little is known regarding the exact role of MFRP in the RPE, its underlying contribution to pathology, and the impacted mechanisms at the early stages of MFRP-related disease. This review presents a current overview of MFRP studies and poses outstanding questions that are crucial for understanding the involvement of MFRP in early-onset retinal degeneration. Such insight could pave the way for deciphering the molecular mechanisms associated with MFRP that are impacted during early stages in the retina, offering the potential to translate this knowledge into determining similarities and differences in mechanisms involved in late-stage retinal diseases.

Indexed as

Membrane ProteinsRetinal DegenerationRetinal Pigment EpitheliumAnimalsEye ProteinsHumansMiceMutationEye ProteinsMembrane ProteinsAMDC1QTNF5/CTRP5MFRPPhotoreceptorsRetinal degenerationRetinitis pigmentosaRPE

Identifiers

PMID39930176

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.