ReviewAdvances in experimental medicine and biology2025
Photoreceptor Degeneration: More Than a Bystander in Age-Related Macular Degeneration.
Review in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Quantum molecular resonance and secretome synergistically unlocks a protective ceRNA axis in the human retinal pigment epithelium.Molecular therapy. Nucleic acids · 2026Article
- Revisiting retinal and macular degeneration in the genomics era.Nature reviews. Genetics · 2026Review
- TEP-1, a glial thioester protein is required for cilia organization and intraflagellar transport in ensheathed sensory neurons inMolecular biology of the cell · 2026Article
- Diagnostic Performance of Ring Aperture Retro Mode Imaging for Detecting Pigment Migration in Age-Related Macular Degeneration.Diagnostics (Basel, Switzerland) · 2025Article
- Age-Related Macular Degeneration: Cellular and Molecular Signaling Mechanisms.International journal of molecular sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Age-related macular degeneration (AMD) is a leading cause of visual impairment affecting nearly 200 million people worldwide, and this number is expected to increase in the coming decades. The role of the retinal pigment epithelium (RPE) in AMD pathogenesis has been extensively studied. However, the contribution of photoreceptor (PR) dysfunction to AMD pathogenesis remains understudied and is a critical gap in our knowledge. The RPE and PRs are coupled to promote and enhance their respective survival and function, and this delicate relationship becomes disrupted in AMD. Furthermore, PR metabolic demands are postulated to contribute to AMD pathogenesis, their dysfunction is associated with both the early and end stages of AMD, and their death is central to the vision loss patient's experience in AMD. Here, we review clinical and basic science data indicating that PRs are likely more than a bystander in AMD and play a significant role in AMD pathogenesis.
Indexed as
Identifiers
39930168What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.